This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
The aim of this proposal is to discover and develop novel anti-infective agents utilizing a natural product core-based library approach. Historically, natural products are known as a rich source of compounds found to be bioactive against a wide range of disease states, in particular as anti-infective drugs or as lead compounds.
Specific Aim 1. Further optimization and development of nucleoside peptide anti-tuberculosis agents. We would like to develop nucleoside peptide mimics as novel anti-tuberculosis agents targeting cell wall biosynthesis. To achieve this goal, we aim to design and synthesize a small focused optimization library based on the hits from our primary screens of a nucleoside peptide discovery library that has great structural similarity to the Mureidomycins.
Specific Aim 2. Design and synthesis of Gallinamide A analogs as potential antimalarial agents. The purpose of this aim is to develop a feasible synthesis that allows rapid access to Gallinamide A analogs for antimalarial screening. To achieve this goal, we will again use a library core based approach to design and synthesize a diversity oriented library based on a Gallinamide A template.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Hawaii
Schools of Medicine
United States
Zip Code
Sun, Zuyue; Schriewer, Jill; Tang, Mingxin et al. (2016) The TGF-β pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol 90:129-38
Sato, Brittany L; Collier, Eric S; Vermudez, Sheryl Anne et al. (2016) Human amnion mesenchymal cells are pro-inflammatory when activated by the Toll-like receptor 2/6 ligand, macrophage-activating lipoprotein-2. Placenta 44:69-79
Rueli, Rachel H L H; Parubrub, Arlene C; Dewing, Andrea S T et al. (2015) Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain. J Alzheimers Dis 44:379-83
Youn, Ui Joung; Sripisut, Tawanun; Park, Eun-Jung et al. (2015) Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett 25:4719-23
Hamad, Mazen Lee; Engen, William; Morris, Kenneth R (2015) Impact of hydration state and molecular oxygen on the chemical stability of levothyroxine sodium. Pharm Dev Technol 20:314-9
Miklossy, Gabriella; Youn, Ui Joung; Yue, Peibin et al. (2015) Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma. J Med Chem 58:7734-48
Panee, Jun; Pang, Xiaosha; Munsaka, Sody et al. (2015) Independent and co-morbid HIV infection and Meth use disorders on oxidative stress markers in the cerebrospinal fluid and depressive symptoms. J Neuroimmune Pharmacol 10:111-21
Tsutsumi, Lissa S; Owusu, Yaw B; Hurdle, Julian G et al. (2014) Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. Curr Top Med Chem 14:152-75
Chan, Yvonne L; Schanzenbach, David; Hickerson, Michael J (2014) Detecting concerted demographic response across community assemblages using hierarchical approximate Bayesian computation. Mol Biol Evol 31:2501-15
Ching, Travers H; Yoza, Brandon A; Li, Qing X (2014) Quartet analysis of putative horizontal gene transfer in Crenarchaeota. J Mol Evol 78:163-70

Showing the most recent 10 out of 136 publications