This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Meeting benchmarks of successful weight management intervention requires that individuals make difficult choices, often involving challenging and sustained efforts of self-control. The proposed research will investigate whether individuals struggling with weight management exhibit characteristic neuro-cognitive indices related to attentional- and self-control and ? because intervention often involves effortful implementation of sustained lifestyle changes ? whether such indices might additionally predict intervention outcomes within a population of such individuals. The following are among the questions to be tested: (1) Do individuals struggling with weight management exhibit marked impulsiveness or difficulties involving attention shifting, working memory, and the inhibition of otherwise reflexive behaviors? Do such indices correlate with objective measures such as BMI and efficacy of intervention over the course of treatment? (2) Are weight management problems accompanied by exaggerated affectively-driven neural responses to food cues and/or by a relative inability to regulate such responses? (3) Do common food cues, such as appetitive aromas generally negatively impact cognitive control functions? These issues will be investigated through the use of objective and proven neuro-physiological and behavioral methods. It is anticipated that data obtained in the initial stages of investigation will set the stage for future funding and research, as well as for building further bridges between the University of Delaware, the A.I duPont Hospital for Children, and INBRE core centers at the Delaware Biotechnology Institute. Furthermore, this project will provide a unique training opportunity for undergraduate and graduate students wishing to work at the interface between clinical and neuro-cognitive research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016472-11
Application #
8359626
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2011-03-01
Project End
2012-02-29
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
11
Fiscal Year
2011
Total Cost
$101,067
Indirect Cost
Name
University of Delaware
Department
Type
Organized Research Units
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Liang, Yingkai; Li, Linqing; Scott, Rebecca A et al. (2017) Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry. Macromolecules 50:483-502
Pathania, Mallika; Wang, Yan; Simirskii, Vladimir N et al. (2016) ?1-integrin controls cell fate specification in early lens development. Differentiation 92:133-147
Mackley, Amy; Winter, Michael; Guillen, Ursula et al. (2016) Health Literacy Among Parents of Newborn Infants. Adv Neonatal Care 16:283-8
Freudenberg, Uwe; Liang, Yingkai; Kiick, Kristi L et al. (2016) Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials. Adv Mater 28:8861-8891
Marnocha, C L; Levy, A T; Powell, D H et al. (2016) Mechanisms of extracellular S0 globule production and degradation in Chlorobaculumtepidum via dynamic cell-globule interactions. Microbiology 162:1125-34
Boukari, Fatima; Makrogiannis, Sokratis; Nossal, Ralph et al. (2016) Imaging and tracking HIV viruses in human cervical mucus. J Biomed Opt 21:96001
Choi, Yong Seok; Lee, Kelvin H (2016) Multiple reaction monitoring assay based on conventional liquid chromatography and electrospray ionization for simultaneous monitoring of multiple cerebrospinal fluid biomarker candidates for Alzheimer's disease. Arch Pharm Res 39:390-7
Brewer-Smyth, Kathleen; Pohlig, Ryan T; Bucurescu, Gabriel (2016) Female children with incarcerated adult family members at risk for lifelong neurological decline. Health Care Women Int 37:802-13
Audette, Dylan S; Anand, Deepti; So, Tammy et al. (2016) Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression. Development 143:318-28
Lindsey, Stephan; Langhans, Sigrid A (2015) Epidermal growth factor signaling in transformed cells. Int Rev Cell Mol Biol 314:1-41

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