This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. According to the latest NHANES survey (1999-2002), 29% of women at childbearing age (20-39 years old) are obese. At the same time, autoimmune diseases including Type I diabetes are also increasing, indicating a likely link between maternal obesity (MO) and altered immune system development. Major components of immune system development are accomplished during the fetal and neonatal stages. Our preliminary data show that MO led to systemic inflammation in fetuses and the expression of toll like receptor (TLR) 4 was elevated. We hypothesized that MO induces systemic inflammation in fetus, which promotes survival of thymocytes specific to host-derived antigens, increasing the incidence of autoimmune diseases including type I diabetes in offspring. We are using well-established non-obese diabetic (NOD) mice fed control (Con) or obesogenic (OB) diet to study the effect of MO on the incidences of offspring type I diabetes. We also utilize TLR4 knockout mice to study the role of TLR4 in the fetal immune system development. Based on the data obtained from this study, the PI will further explore mechanisms associated with the fetal immune system development and immune tolerance, and develop specific strategies to cope with autoimmune diseases. Knowledge obtained in this study will provide targets for interventions to ensure the proper development of the immune system, improving the quality of life for the offspring of the increasing number of obese pregnant women in this country.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016474-11
Application #
8359735
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
11
Fiscal Year
2011
Total Cost
$34,228
Indirect Cost
Name
University of Wyoming
Department
Type
Schools of Allied Health Profes
DUNS #
069690956
City
Laramie
State
WY
Country
United States
Zip Code
82071
Jiang, Zhongliang; Xia, Bingzhao; McBride, Ralph et al. (2017) A microfluidic-based cell encapsulation platform to achieve high long-term cell viability in photopolymerized PEGNB hydrogel microspheres. J Mater Chem B 5:173-180
Mahat, Rajendra; Seebart, Corrine; Basile, Franco et al. (2016) Global and Targeted Lipid Analysis of Gemmata obscuriglobus Reveals the Presence of Lipopolysaccharide, a Signature of the Classical Gram-Negative Outer Membrane. J Bacteriol 198:221-36
Thomas, Jenifer J; Moring, John C; Harvey, Terra et al. (2016) Risk of type 2 diabetes: health care provider perceptions of prevention adherence. Appl Nurs Res 32:1-6
Edwards, Brian S; Dang, An K; Murtazina, Dilyara A et al. (2016) Dynamin Is Required for GnRH Signaling to L-Type Calcium Channels and Activation of ERK. Endocrinology 157:831-43
Kapali, Jyoti; Kabat, Brock E; Schmidt, Kelly L et al. (2016) Foxo1 Is Required for Normal Somatotrope Differentiation. Endocrinology 157:4351-4363
Krutkramelis, K; Xia, B; Oakey, J (2016) Monodisperse polyethylene glycol diacrylate hydrogel microsphere formation by oxygen-controlled photopolymerization in a microfluidic device. Lab Chip 16:1457-65
Boyle, Diane K; Jayawardhana, Ananda; Burman, Mary E et al. (2016) A pressure ulcer and fall rate quality composite index for acute care units: A measure development study. Int J Nurs Stud 63:73-81
Larson-Meyer, D Enette; Schueler, Jessica; Kyle, Erin et al. (2016) Do Lactation-Induced Changes in Ghrelin, Glucagon-Like Peptide-1, and Peptide YY Influence Appetite and Body Weight Regulation during the First Postpartum Year? J Obes 2016:7532926
Reece, Amy E; Oakey, John (2016) Long-range forces affecting equilibrium inertial focusing behavior in straight high aspect ratio microfluidic channels. Phys Fluids (1994) 28:043303
Hua, Yinan; Nair, Sreejayan (2015) Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications. Biochim Biophys Acta 1852:195-208

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