The University of Kansas Medical Center (KUMC) here presents an application for continued support for the Kansas IDeA Network for Biomedical Research Excellence (K-INBRE). The K-INBRE links KUMC (Lead Institution) with the two other major doctoral-degree-granting institutions in Kansas (University of Kansas-Lawrence, KU-L;Kansas State University, KSU) as Graduate Partner Institutions (GPI) and with seven Undergraduate Partner Institutions (UPI). UPI include six Kansas undergraduate campuses (Emporia State University, Ft. Hays State University, Haskell Indian Nations University, Pittsburgh State University, Washburn University, Wichita State University) and Langston University (Langston, OK). Haskell Indian Nations University and Langston University increase diversity in the network as the first is devoted to education and training of native Americans and the second enrolls primarily black undergraduates. The long-range objective of the Kansas program is to strengthen the state's research capacity in Cell and Developmental Biology by building on the successes of the current K-INBRE. The size, structure and operational principles of the K-INBRE, which include strong emphasis on training for biomedical research, networking and intercampus communication and the establishment of a sophisticated bioinformatics program, were established during the previous years of support. These goals remain basically the same as the K-INBRE has had a major positive impact on biomedical research in the State of Kansas. Programs conducted by the K-INBRE have had measurable success in reaching their stated goals as well as those of the NCRR IDeA program.
The Specific Aims proposed for the next phase of the K-INBRE are to (1) maintain and improve the current multi-disciplinary research network in Cell and Developmental Biology with efficient administration and focus on networking, (2) enhance science and technology knowledge and integration by offering sophisticated bioinformatics technology and education, (3) facilitate translational research via bidirectional exchange of basic and clinical scientist training opportunities. Within these Aims, new features that improve the K-INBRE include broadening funding for research careers together with improvements in oversight and the mentoring process, promoting an integrated systems biology approach within our bioinformatics network, and incorporating training for translational research into the K-INBRE goals so as to smooth the progress of scientific discoveries into the clinical arena.

Public Health Relevance

(provided by applicant): Research in cell and developmental biology is essential to advancing our understanding of cellular processes of health and disease. Such research relies on generation of a strong, well educated workforce, ready availability of the tools of discovery and emphasis on applying the results of discovery research to problems of human health. In building a distinguished center of research in cell and developmental biology in Kansas, the K-INBRE vigorously pursues all three of these key strategies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016475-10
Application #
7799955
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Program Officer
Douthard, Regine
Project Start
2001-09-18
Project End
2014-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
10
Fiscal Year
2010
Total Cost
$3,622,489
Indirect Cost
Name
University of Kansas
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Pang, Xiao-Yan; Wang, Suya; Jurczak, Michael J et al. (2017) Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Arch Biochem Biophys 633:93-102
Barton, Janice S; Schomacker, Rachel (2017) Comparative protein profiles of the Ambrosia plants. Biochim Biophys Acta 1865:633-639
Dowdell, Alexander S; Murphy, Maxwell D; Azodi, Christina et al. (2017) Comprehensive Spatial Analysis of the Borrelia burgdorferi Lipoproteome Reveals a Compartmentalization Bias toward the Bacterial Surface. J Bacteriol 199:
Chakrabarti, Rima S; Ingham, Sally A; Kozlitina, Julia et al. (2017) Variability of cholesterol accessibility in human red blood cells measured using a bacterial cholesterol-binding toxin. Elife 6:
Bowden, John A; Heckert, Alan; Ulmer, Candice Z et al. (2017) Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res 58:2275-2288
Guilford, B L; Ryals, J M; Lezi, E et al. (2017) Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet. J Neurol Neurosci 8:
Rogers, Robert S; Tungtur, Sudheer; Tanaka, Tomohiro et al. (2017) Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice. Front Neurosci 11:473
Moon, Sanghee; Schmidt, Marshall; Smirnova, Irina V et al. (2017) Qigong Exercise May Reduce Serum TNF-? Levels and Improve Sleep in People with Parkinson's Disease: A Pilot Study. Medicines (Basel) 4:
Pook, Victoria G; Nair, Meera; Ryu, KookHui et al. (2017) Positioning of the SCRAMBLED receptor requires UDP-Glc:sterol glucosyltransferase 80B1 in Arabidopsis roots. Sci Rep 7:5714
Kania-Korwel, Izabela; Wu, Xianai; Wang, Kai et al. (2017) Identification of lipidomic markers of chronic 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134

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