This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In the budding yeast Saccharomyces cerevisiae, large-scale gene deletion analysis has shown that over 80% of the ~6200 yeast genes are non-essential, implying that many genes and pathways in eukaryotic cells must be functionally redundant or buffered from phenotypic consequences following genetic perturbation. I am interested in exploring this functional redundancy, especially as it relates to transcriptional regulatory networks. A number of uncharacterized open reading frames (ORFs) have sequence homology to well known families of transcription factors. Using high-throughput genetic analysis (Synthetic Genetic Array Analysis, or SGA), DNA microarrays, and Genome-wide location analysis or Chip on chip, I would like to connect one or more of these uncharacterized putative regulatory genes with a new or existing physiologically significant pathway.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016476-10
Application #
8360565
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2011-06-01
Project End
2012-05-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
10
Fiscal Year
2011
Total Cost
$76,230
Indirect Cost
Name
University of Southern Mississippi
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
623335775
City
Hattiesburg
State
MS
Country
United States
Zip Code
39406
Das, Pradipta K; Dean, Dexter N; Fogel, April L et al. (2017) Aqueous RAFT Synthesis of Glycopolymers for Determination of Saccharide Structure and Concentration Effects on Amyloid ? Aggregation. Biomacromolecules 18:3359-3366
Rana, Pratip; Dean, Dexter N; Steen, Edward D et al. (2017) Fatty Acid Concentration and Phase Transitions Modulate A? Aggregation Pathways. Sci Rep 7:10370
Budachetri, Khemraj; Crispell, Gary; Karim, Shahid (2017) Amblyomma maculatum SECIS binding protein 2 and putative selenoprotein P are indispensable for pathogen replication and tick fecundity. Insect Biochem Mol Biol 88:37-47
Budachetri, Khemraj; Williams, Jaclyn; Mukherjee, Nabanita et al. (2017) The microbiome of neotropical ticks parasitizing on passerine migratory birds. Ticks Tick Borne Dis 8:170-173
Dean, Dexter N; Das, Pradipta K; Rana, Pratip et al. (2017) Strain-specific Fibril Propagation by an A? Dodecamer. Sci Rep 7:40787
Budachetri, K; Kumar, D; Karim, S (2017) Catalase is a determinant of the colonization and transovarial transmission of Rickettsia parkeri in the Gulf Coast tick Amblyomma maculatum. Insect Mol Biol 26:414-419
Ghosh, Preetam; Vaidya, Ashwin; Kumar, Amit et al. (2016) Determination of critical nucleation number for a single nucleation amyloid-? aggregation model. Math Biosci 273:70-9
Amato, Dahlia N; Amato, Douglas V; Mavrodi, Olga V et al. (2016) Destruction of Opportunistic Pathogens via Polymer Nanoparticle-Mediated Release of Plant-Based Antimicrobial Payloads. Adv Healthc Mater 5:1094-103
Chakraborty, Sandipan; Kumar, Avinash; Butt, Nasir A et al. (2016) Molecular insight into the differential anti-androgenic activity of resveratrol and its natural analogs: in silico approach to understand biological actions. Mol Biosyst 12:1702-9
Chakraborty, S; Asare, B K; Biswas, P K et al. (2016) Designer interface peptide grafts target estrogen receptor alpha dimerization. Biochem Biophys Res Commun 478:116-122

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