This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Oklahoma State University (OSU) Microarray Core Facility (OMCF) and its associated bioinformatics group, BioinfOSU, provide facilities, consultation, education and training. Their facilities include modern instruments for the preparation of microarrays of oligo- and polynucleotides, for their hybridization to labeled target nucleic acids, for scanning the fluorescent intensities of spots after hybridization and for computational analysis of the results. Staff includes a Ph. D. faculty-level microarray specialist with extensive bioinformatics experience, an applications programmer versed in microarray data handling and a systems administrator. All personnel positions have been transitioned to permanent full-time positions insuring the continued support of research at Oklahoma State University and beyond. To demonstrate that such staff and facilities stimulate and facilitate research in functional genomics, OMCF and BioinfOSU provide workshops and consultation services to investigators of all levels, as well as making their resources generally available. Groups led by more than 25 Principal Investigators use OSU microarray and bioinformatics facilities to study a diverse range of organisms: Amblyomma americanum (lone star tick), Campylobacter jejuni, Cynodon dactylon (bermuda grass), Emericella nidulans, Gossypium hirsutum (cotton), Influenza viruses, Lycopersicon esculentum (tomato), Rattus norvegicus (rat), Sorghum, Synechocystis sp. PCC6803, Triticum aestivum (bread wheat), Medicago truncatula, Mus musculus, Homo sapiens, Dunaliella spp., Aspergillis nidulans, Cricetus (Chinese hamster ovary cells), Bos taurus (cow), and various pathogenic microbes. The work supported by the facility has led to publications in peer-reviewed journals (see section G). In addition to training graduate and postdoctoral students, the scientists leading these laboratories annually welcome numerous undergraduate students into their laboratories to participate in the research. Feedback from clients continually improves the ability of the facilities to provide services and advice.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
2P20RR016478-09
Application #
7960008
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
2009-05-01
Project End
2010-03-31
Budget Start
2009-05-01
Budget End
2010-03-31
Support Year
9
Fiscal Year
2009
Total Cost
$108,416
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2018) Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis. Sci Rep 8:7805
Wetherill, Marianna S; Williams, Mary B; Gray, Karen A (2017) SNAP-Based Incentive Programs at Farmers' Markets: Adaptation Considerations for Temporary Assistance for Needy Families (TANF) Recipients. J Nutr Educ Behav 49:743-751.e1
Hannafon, Bethany N; Trigoso, Yvonne D; Calloway, Cameron L et al. (2016) Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res 18:90
Wilson, Kevin R; Cannon-Smith, Desiray J; Burke, Benjamin P et al. (2016) Synthesis and structural studies of two pyridine-armed reinforced cyclen chelators and their transition metal complexes. Polyhedron 114:118-127
Trigoso, Yvonne D; Evans, Russell C; Karsten, William E et al. (2016) Cloning, Expression, and Purification of Histidine-Tagged Escherichia coli Dihydrodipicolinate Reductase. PLoS One 11:e0146525
Khandaker, Morshed; Riahinezhad, Shahram; Sultana, Fariha et al. (2016) Peen treatment on a titanium implant: effect of roughness, osteoblast cell functions, and bonding with bone cement. Int J Nanomedicine 11:585-94
Hu, Zihua; Jiang, Kaiyu; Frank, Mark Barton et al. (2016) Complexity and Specificity of the Neutrophil Transcriptomes in Juvenile Idiopathic Arthritis. Sci Rep 6:27453
Jones, Donald G; Wilson, Kevin R; Cannon-Smith, Desiray J et al. (2015) Synthesis, structural studies, and oxidation catalysis of the late-first-row-transition-metal complexes of a 2-pyridylmethyl pendant-armed ethylene cross-bridged cyclam. Inorg Chem 54:2221-34
Wetherill, Marianna S; Gray, Karen A (2015) Farmers' markets and the local food environment: identifying perceived accessibility barriers for SNAP consumers receiving temporary assistance for needy families (TANF) in an urban Oklahoma community. J Nutr Educ Behav 47:127-33.e1
Butler, Noah S; Kulu, Divine I (2015) The regulation of T follicular helper responses during infection. Curr Opin Immunol 34:68-74

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