This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this research is to investigate quantum dot-polythiophene-DNA complexes as a means to deliver therapeutic agents to site-specific locations using fluorescence resonance energy transfer (FRET). The FRET technique will be used to induce the release of a therapeutic agent that is attached to a strand of DNA. The use of the quantum dot is to facilitate energy absorption from light at narrow wavelengths and the conducting polymer polythiophene is used as an energy-transfer conduit since quantum dots are difficult to attach to DNA. Initial studies will focus on the energy transfer from the quantum dot to the DNA. Following studies may involve attaching photocleavable groups to any part of the complex. I will collaborate with researchers at the University of South Dakota Chemistry and Biomedical Research Departments and my part is to synthesize polythiophenes that will link the quantum dot and the DNA strand.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-4 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of South Dakota
Other Basic Sciences
Schools of Medicine
United States
Zip Code
Bonilla, José Oscar; Callegari, Eduardo Alberto; Delfini, Claudio Daniel et al. (2016) Simultaneous chromate and sulfate removal by Streptomyces sp. MC1. Changes in intracellular protein profile induced by Cr(VI). J Basic Microbiol :
Callegari, Eduardo A (2016) Shotgun Proteomics Analysis of Estrogen Effects in the Uterus Using Two-Dimensional Liquid Chromatography and Tandem Mass Spectrometry. Methods Mol Biol 1366:131-48
Zhang, Fan; Hartnett, Sigurd; Sample, Alex et al. (2016) High fat diet induced alterations of atrial electrical activities in mice. Am J Cardiovasc Dis 6:1-9
Herrera, Andrea L; Huber, Victor C; Chaussee, Michael S (2016) The Association between Invasive Group A Streptococcal Diseases and Viral Respiratory Tract Infections. Front Microbiol 7:342
Wu, Steven C; OʼConnell, Timothy D (2015) Nuclear compartmentalization of α1-adrenergic receptor signaling in adult cardiac myocytes. J Cardiovasc Pharmacol 65:91-100
Mardones, Wladimir; Callegari, Eduardo; Eyzaguirre, Jaime (2015) Heterologous expression of a Penicillium purpurogenum exo-arabinanase in Pichia pastoris and its biochemical characterization. Fungal Biol 119:1267-78
Wu, Steven C; OʼConnell, Timothy D (2015) A nuclear option? G-protein coupled receptors at the nucleus in cardiac myocytes. J Cardiovasc Pharmacol 65:89-90
Haag, Nichole; Velk, Kimberly; McCune, Tyler et al. (2015) Bioinformatics and Molecular Biological Characterization of a Hypothetical Protein SAV1226 as a Potential Drug Target for Methicillin/Vancomycin-Staphylococcus aureus Infections. World Acad Sci Eng Technol 9:587-591
Hartnett, Sigurd; Zhang, Fan; Abitz, Allison et al. (2014) Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells. Neurosci Lett 564:115-9
Vastenhout, Kayla J; Tornberg, Ruthellen H; Johnson, Amanda L et al. (2014) High-performance liquid chromatography-based method to evaluate kinetics of glucosinolate hydrolysis by Sinapis alba myrosinase. Anal Biochem 465:105-13

Showing the most recent 10 out of 110 publications