This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on CVD risk factors, including blood pressure (BP), body weight and composition, serum lipids, plasma glucose, insulin, adipocytokines (adiponectin, leptin, resistin), and C-reactive protein (CRP) among obese adults. This study is a randomized controlled trial with a two-arm, parallel design. Using a stratified, blocked randomization scheme, eligible participants are assigned to either a low-carbohydrate intervention diet or a low fat control diet (instructions for each group will include intensive one-on-one counseling with a dietitian every week for 4 weeks followed by 10 biweekly sessions and 6 monthly sessions). This trial has 80% statistical power to detect clinically important changes in CVD risk factors. In order to conduct the trial, we will recruit 130 study participants with a body mass index of 30-45 kg/m2 using mass mailings, workplace screenings, community health fairs, and media advertisements in the Greater New Orleans, LA area;randomize the eligible participants to either a low-carbohydrate intervention diet for 12 months or a low fat diet for 12 months;provide diet instructions for each participant including intensive one-on-one counseling with a dietitian for a total of 15 sessions over 12 months;measure CVD risk factors (systolic and diastolic BP, body weight, body composition, waist circumference, lipid profiles, glucose and insulin levels, and levels of CRP and adipocytokines) in all participants at baseline, 3, 6, and 12 months of follow-up;and examine the differences in these risk factors among persons assigned to the low-carbohydrate intervention compared to those assigned to the low fat intervention.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017659-10
Application #
8360256
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2011-07-01
Project End
2012-07-31
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$221,263
Indirect Cost
Name
Tulane University
Department
Physiology
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Gonzalez, Alexis A; Zamora, Leonardo; Reyes-Martinez, Cristian et al. (2017) (Pro)renin receptor activation increases profibrotic markers and fibroblast-like phenotype through MAPK-dependent ROS formation in mouse renal collecting duct cells. Clin Exp Pharmacol Physiol 44:1134-1144
Hu, Tian; Yao, Lu; Reynolds, Kristi et al. (2016) Adherence to low-carbohydrate and low-fat diets in relation to weight loss and cardiovascular risk factors. Obes Sci Pract 2:24-31
Li, Wencheng; Sullivan, Michelle N; Zhang, Sheng et al. (2015) Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension. Hypertension 65:352-61
Li, Yuwen; Liu, Jiao; Li, Wencheng et al. (2015) p53 Enables metabolic fitness and self-renewal of nephron progenitor cells. Development 142:1228-41
Dobrowolski, Leszek; Kuczeriszka, Marta; Castillo, Alexander et al. (2015) Role of atrial natriuretic peptide in mediating the blood pressure-independent natriuresis elicited by systemic inhibition of nitric oxide. Pflugers Arch 467:833-41
Gonzalez, Alexis A; Prieto, Minolfa C (2015) Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review. Ther Adv Cardiovasc Dis 9:191-200
Gonzalez, Alexis A; Prieto, Minolfa C (2015) Renin and the (pro)renin receptor in the renal collecting duct: Role in the pathogenesis of hypertension. Clin Exp Pharmacol Physiol 42:14-21
Hu, Tian; Yao, Lu; Reynolds, Kristi et al. (2015) The Effects of a Low-Carbohydrate Diet vs. a Low-Fat Diet on Novel Cardiovascular Risk Factors: A Randomized Controlled Trial. Nutrients 7:7978-94
Chen, Jing; Hamm, L Lee; Mohler, Emile R et al. (2015) Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease. PLoS One 10:e0132047
Rivara, Matthew B; Ikizler, T Alp; Ellis, Charles D et al. (2015) Association of plasma F2-isoprostanes and isofurans concentrations with erythropoiesis-stimulating agent resistance in maintenance hemodialysis patients. BMC Nephrol 16:79

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