This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The mission of the CCRD is to create, interpret, and apply new knowledge based on original, collaborative, multidisciplinary laboratory studies of the cellular and molecular pathways leading to gastrointestinal cancer. This broad area of research is represented by investigators pursuing research relevant to four major themes - Theme A - The significance of fetal proteins and phenotypes in Cancer;Theme B - Pathogenesis Of GI Tumors;Theme C - Signal Transduction Mechanisms Relevant to Carcinogenesis;Theme D - Role of RNA and DNA Viruses in Cancer. The center is advised by the External Advisory Committee (EAC), which includes 5 distinguished scientists: Daniel Flynn, PhD (Chair and Director of the COBRE Center for Signal Transduction and Cancer in West Virginia);Susan Fischer, PhD (MD Anderson Cancer Center);Nelson Fausto, MD (Univ. of Wash., Chair of Pathology);Harriet Isom, PhD (Penn State Cancer Inst./M.S. Hershey Med. Center Dist.Prof. Microbiolgy, Immunology and Pathology); and Alan Rosmarin, MD (Chief, Division of Hematology Oncology and Deputy Directof of University of Massachusetts Memorial Cancer Center). The EAC provided advisement to leadership of the COBRE CCRD, also known as the Internal Executive Committee (IEC). The IEC includes the Core Directors: Douglas Hixson PhD (Dir.Core A);Djuro Josic, PhD (Dir. Core B);Ronald DeLellis, MD (Dir. Core C), Murray Resnick, MD, PhD (Co-Dir. Core C);the Deputy Director, Jonathan Reichner, PhD; and the mentors: Philip Grupposo, MD;Peter Quesenberry, MD;and Jack Wands, MD. The COBRE CCRD website can be found at www.lifespan.org/rih/services/cobre. It lists NCRR funding for this Center.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017695-08
Application #
8359710
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
8
Fiscal Year
2011
Total Cost
$445,215
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
Lopez, Chelsea E; Sheehan, Hannah C; Vierra, David A et al. (2017) Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis. Biol Open 6:943-955
Francois-Vaughan, Heather; Adebayo, Adeola O; Brilliant, Kate E et al. (2016) Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma. Carcinogenesis 37:408-419
Li, Ming; Tucker, Lynne D; Asara, John M et al. (2016) Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. J Clin Invest 126:3117-29
Breen, Lucas D; Pu?i?-Bakovi?, Maja; Vu?kovi?, Frano et al. (2016) IgG and IgM glycosylation patterns in patients undergoing image-guided tumor ablation. Biochim Biophys Acta 1860:1786-94
Mulvey, Hillary E; Chang, Audrey; Adler, Jason et al. (2015) Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells. BMC Cancer 15:571
Cheng, Yan; Holloway, Michael P; Nguyen, Kevin et al. (2014) XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer. Mol Cancer Ther 13:675-86
Yousuf, Saad; Duan, MeiLi; Moen, Erika L et al. (2014) Raf kinase inhibitor protein (RKIP) blocks signal transducer and activator of transcription 3 (STAT3) activation in breast and prostate cancer. PLoS One 9:e92478
Cao, Weibiao; Tian, Wei; Hong, Jie et al. (2013) Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Physiol Gastrointest Liver Physiol 304:G322-7
Panagopoulos, Kiriaki; Cross-Knorr, Sam; Dillard, Christen et al. (2013) Reversal of chemosensitivity and induction of cell malignancy of a non-malignant prostate cancer cell line upon extracellular vesicle exposure. Mol Cancer 12:118
Perez, K; Walsh, R; Brilliant, K et al. (2013) Heterogeneity of colorectal cancer (CRC) in reference to KRAS proto-oncogene utilizing WAVE technology. Exp Mol Pathol 95:74-82

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