This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Histology and Imaging Core will be housed in the University of South Carolina School of Medicine Instrumentation Resource Facilty (IRF) which is an existing core facility serving the entire USC research environment. As in the current COBRE grant, the purpose of the Histology and Imaging is to: A) provide access to state-of-the-art expensive instrumentation; B) Provide the expertise to efficiently operate the equipment; C) to provide assistance in the interpretation of data generated in the Core for the preparation of experiments, grants and publications. As a core resource for the CCCR COBRE there are three primary goals: 1) to provide access to all equipment and technical expertise in the IRF for CCCR COBRE Target Faculty through the Biotechnology Core budget so that no Target Investigators will pay IRF user fees;2) to provide an improved avenue of communication for collaborations with research faculty within the IRF for Junior and Senior CCCR COBRE Investigators;and 3) to provide improved infrastructure capabilities for the entire University of South Carolina research environment. During the first four years of the existing COBRE grant the Core has interacted with most junior and senior faculty members affiliated with the CCCR COBRE. All Junior Investigators, including Target Faculty as well as new hires, have received free use of the IRF equipment and technicians through compensation to the IRF by the Histology and Imaging Core budget. Although the current group of COBRE Junior and Senior investigators represent approximately 30% of the total use of the IRF, the facility has a large and diverse user base that includes investigators from a number of colleges within the University of South Carolina. The diverse group of users, along with financial support from the School of Medicine (currently $300,000/year) insures the continued viability of the Core after the completion of the second five year period of the COBRE.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017698-10
Application #
8360348
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2011-06-01
Project End
2013-05-31
Budget Start
2011-06-01
Budget End
2013-05-31
Support Year
10
Fiscal Year
2011
Total Cost
$176,803
Indirect Cost
Name
University of South Carolina at Columbia
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Oliver, David; Ji, Hao; Liu, Piaomu et al. (2017) Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep 7:43023
Mentrup, Heather L; Hartman, Amanda; Thames, Elizabeth L et al. (2017) The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration. Differentiation 99:51-61
Chumanevich, Anastasiya A; Chaparala, Anusha; Witalison, Erin E et al. (2017) Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds. Oncotarget 8:228-237
Alexander, M; Burch, J B; Steck, S E et al. (2017) Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis 32:183-192
Zhang, Yu; Davis, Celestia; Shah, Sapana et al. (2017) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56:272-287
Gao, Feng J; Shi, Liang; Hines, Timothy et al. (2017) Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell 28:587-599
Gao, Song; Carson, James A (2016) Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes. Am J Physiol Cell Physiol 310:C66-79
Peña, Edsel A (2016) Asymptotics for a Class of Dynamic Recurrent Event Models. J Nonparametr Stat 28:716-735
Kindo, Bereket P; Wang, Hao; Peña, Edsel A (2016) Multinomial probit Bayesian additive regression trees. Stat (Int Stat Inst) 5:119-131
Carson, James A; Hardee, Justin P; VanderVeen, Brandon N (2016) The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting. Semin Cell Dev Biol 54:53-67

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