This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Despite the benefits of modern brain imaging in living patients and the numerous animal models of psychiatric illness, there will always be a significant need for the analysis of actual brain tissue postmortem. Studies on postmortem tissues can zero in on individual neurons and their helper cells, neuroglia, to assess cellular anatomic features, protein expression and interactions with processes from other individual nerve cells revealing information not attainable from living patients or animal models. The CPN Human Brain Collection Core is directed by Dr. Craig A. Stockmeier, Core Leader. Dr. Stockmeier has extensive experience in the development and management of one of the leading postmortem human brain collections in the country devoted specifically to psychiatric neuroscience.The Human Brain Collection was funded by the National Institute of Mental Health from 1989 through 2007 and is funded by NCRR from 2007 through 2012. The brain collection is run in collaboration with the Departments of Psychiatry and Psychology, Case Western Reserve University, Cleveland, Ohio, and with the Cuyahoga County Coroner Office, Cleveland, Ohio. The psychiatric assessment team includes James C. Overholser, Ph.D. and George J. Jurjus, M.D. Dr. Overholser, a clinical psychologist, has a long-standing career interest in depressive disorders in adolescents and adults. Dr. Jurjus, Director of Inpatient Psychiatry and Detoxification at the Cleveland Wade Park VA Hospital, has been part of the retrospective diagnostic team since 1997 and provides additional expertise in psychoactive substance use disorders. Dr. Stockmeier and his collaborators organize all aspects of the brain collection, including storage of tissue samples and accompanying clinical information. CPN Project Principal Investigators are provided with high-quality postmortem human brain samples meeting inclusion criteria for their research aims involving psychiatric illnesses, as well as the critical supporting information for the brain tissue. Dr. Stockmeier further advises CPN investigators in the selection and matching of appropriate control and psychiatric subjects for their biological studies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR017701-10
Application #
8360503
Study Section
Special Emphasis Panel (ZRR1-RI-5 (01))
Project Start
2011-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$298,172
Indirect Cost
Name
University of Mississippi Medical Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216
Stoppelbein, Laura; McRae, Elizabeth; Greening, Leilani (2017) A Longitudinal Study of Hardiness as a Buffer for Posttraumatic Stress Symptoms in Mothers of Children with Cancer. Clin Pract Pediatr Psychol 5:149-160
Greening, Leilani; Stoppelbein, Laura; Cheek, Kara (2017) Racial/ethnic disparities in the risk of posttraumatic stress disorder symptoms among mothers of children diagnosed with cancer and Type-1 diabetes mellitus. Psychol Trauma 9:325-333
Ginley, Meredith K; Bagge, Courtney L (2017) Psychiatric heterogeneity of recent suicide attempters: A latent class analysis. Psychiatry Res 251:1-7
Duncan, Jeremy W; Zhang, Xiao; Wang, Niping et al. (2016) Binge ethanol exposure increases the Krüppel-like factor 11-monoamine oxidase (MAO) pathway in rats: Examining the use of MAO inhibitors to prevent ethanol-induced brain injury. Neuropharmacology 105:329-340
Stewart, Courtney; Yu, Yue; Huang, Jun et al. (2016) Effects of high intensity noise on the vestibular system in rats. Hear Res 335:118-127
Dalwadi, Dhwanil A; Kim, Seongcheol; Amdani, Shahnawaz M et al. (2016) Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz. Pharmacol Res 110:10-24
Fisher, Lauren B; Overholser, James C; Dieter, Lesa (2015) Methods of committing suicide among 2,347 people in Ohio. Death Stud 39:39-43
Stoppelbein, Laura; Greening, Leilani (2015) A longitudinal study of the role of cortisol in posttraumatic stress disorder symptom clusters. Anxiety Stress Coping 28:17-30
Duncan, Jeremy; Wang, Niping; Zhang, Xiao et al. (2015) Chronic Social Stress and Ethanol Increase Expression of KLF11, a Cell Death Mediator, in Rat Brain. Neurotox Res 28:18-31
Johnson, Shakevia; Duncan, Jeremy; Hussain, Syed A et al. (2015) The IFN?-PKR pathway in the prefrontal cortex reactions to chronic excessive alcohol use. Alcohol Clin Exp Res 39:476-84

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