This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hawaii's geographic location as a prominent international port and its strategic proximity to Asia makes it a natural sentinel post from which to monitor the emergence and spread of microbial pathogens and to investigate outbreaks of emerging infectious diseases in the Asia-Pacific region. A fully State-financed state-of-the-art BSL-3/ABSL-3 biocontainment facility is now operational in the constructed BioSciences Building. As the only facility of its kind for researchers in the entire State, the Biocontainment Core serves as a valuable regional asset and will meet the significantly expanded needs and usage. COBRE funds will enhance the infrastructure for the BSL-3/ABSL-3 Biocontainment Core, in support of hypothesis-driven research projects that seek to gain new knowledge for the development of more effective treatments and affordable preventive vaccines. Directed by a senior virologist with assistance from a well-trained staff, the BSL-3/ABSL-3 Biocontainment Core will provide opportunities for developing new methods and techniques for studying pathogenic microbes under BSL-3 biocontainment;also, the Core will provide regularly scheduled training workshops and assist in the certification and permitting process for Core users. Thus, the mission of the Core will achieve the triad of service, research and development, and education and training.
Specific Aim 1. Enhance support and services in BSL-3/ABSL-3 biocontainment.
Specific Aim 2. Develop innovative and improved microbiological assays for research on BSL-3/ABSL-3 microbial pathogens.
Specific Aim 3. Develop and implement training and education workshops in biocontainment-related technology.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
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Special Emphasis Panel (ZRR1-CR-B (01))
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University of Hawaii
Schools of Medicine
United States
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Martin, Estelle; Chirivella, Maritza; Co, Juliene K G et al. (2016) Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence. Virus Res 213:23-31
Roe, Kelsey; Orillo, Beverly; Verma, Saguna (2014) West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model. PLoS One 9:e102598
Anderson, Cynthia D; Urschitz, Johann; Khemmani, Mark et al. (2013) Ultrasound directs a transposase system for durable hepatic gene delivery in mice. Ultrasound Med Biol 39:2351-61
Darrow, April L; Maresh, J Gregory; Shohet, Ralph V (2013) Mouse models and techniques for the isolation of the diabetic endothelium. ISRN Endocrinol 2013:165397
Sana, Theodore R; Gordon, D Benjamin; Fischer, Steven M et al. (2013) Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum. PLoS One 8:e60840
Thongsripong, Panpim; Green, Amy; Kittayapong, Pattamaporn et al. (2013) Mosquito vector diversity across habitats in central Thailand endemic for dengue and other arthropod-borne diseases. PLoS Negl Trop Dis 7:e2507
Arai, Satoru; Gu, Se Hun; Baek, Luck Ju et al. (2012) Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea. Virology 424:99-105
Allicock, Orchid M; Lemey, Philippe; Tatem, Andrew J et al. (2012) Phylogeography and population dynamics of dengue viruses in the Americas. Mol Biol Evol 29:1533-43
Kelley, James F; Kaufusi, Pakieli H; Nerurkar, Vivek R (2012) Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability. Virology 422:326-37
Hernandez, Brenda Y; Ton, Thien; Shvetsov, Yurii B et al. (2012) Human papillomavirus (HPV) L1 and L1-L2 virus-like particle-based multiplex assays for measurement of HPV virion antibodies. Clin Vaccine Immunol 19:1348-52

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