The specific aims for the COBRE for Perinatal Biology are to continue our scientific contributions to the field of perinatal biology and to further development of the research enterprise at Women &Infants Hospital. The common theme of this proposal is that mechanisms for regulation of development during the fetal or early postnatal period can inform importantly the regulatory mechanisms governing cell function, organ maturation, health and disease in later life. This theme is highlighted in the projects will support: 1) host pathogen interactions, developmental immunology and the molecular pathogenesis of yeast infections of Candida albicans in the preterm infant;2) DMA methylation and chromatin remodeling as a biomolecular """"""""fingerprint"""""""" in the placenta for adverse intrauterine life and fetal programming;3) the role of hypoxia and hypoxia-regulated genes in early embryogenesis and implantation;4) recapitulation of the """"""""fetal gene program"""""""" during stem cell repair of cardiac injury in adult life;5) the immunopathogenesis of preeclampsia;6) role of natural killer cells in successful pregnancy outcomes. The programmatic aims of this COBRE are to continue to provide scientific and career mentorship to Junior Faculty in an interdisciplinary environment that fosters creativity and transdisciplinary collaboration in scientific approaches. Using resources from our prior period of support we have developed a robust perinatal research center in the Kilguss Research Institute which has become a state-of-the-art research facility. It houses the majority of this group of junior scientists, all of whom have demonstrated excellent potential for independent careers, as well as successful, senior investigators. This award will allow us to continue to leverage our programs and the environment we have created into the kinds of support needed by all junior investigators to become successful independent investigators. The award will allow them to collaborate with leading scientists in their fields and to utilize contemporary approaches in cell and molecular biology to address important issues in perinatal and developmental biology. The combination of a supportive environment within a robust setting of inquiry and exploration will allow us to enhance/ensure their career trajectories as independent investigators. The clinical relevance of these areas is borne out by their high likelihood to identify important mechanisms during development which inform the pathogenesis of disease across the life spectrum. This program is based at the Women &Infants Hospital of Rhode Island. It will provide support for four full projects and 2 pilot projects of Junior Faculty who will me mentored by established investigators from. An outstanding group of investigators from other centers will provide support and collaboration as the External Scientific Advisory Committee.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-6 (01))
Program Officer
Canto, Maria Teresa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Women and Infants Hospital-Rhode Island
United States
Zip Code
Patra, Aparna; Chen, Xiaodi; Sadowska, Grazyna B et al. (2017) Neutralizing anti-interleukin-1? antibodies reduce ischemia-related interleukin-1? transport across the blood-brain barrier in fetal sheep. Neuroscience 346:113-125
Taggart, Allison J; Lin, Chien-Ling; Shrestha, Barsha et al. (2017) Large-scale analysis of branchpoint usage across species and cell lines. Genome Res 27:639-649
Monahan, Zachary; Ryan, Veronica H; Janke, Abigail M et al. (2017) Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. EMBO J 36:2951-2967
Kao, Hung-Teh; Ryoo, Kanghyun; Lin, Albert et al. (2017) Synapsins regulate brain-derived neurotrophic factor-mediated synaptic potentiation and axon elongation by acting on membrane rafts. Eur J Neurosci 45:1085-1101
Kalkunte, Satyan; Huang, Zheping; Lippe, Eliana et al. (2017) Polychlorinated biphenyls target Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Sci Rep 7:39885
Conicella, Alexander E; Zerze, Gül H; Mittal, Jeetain et al. (2016) ALS Mutations Disrupt Phase Separation Mediated by ?-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain. Structure 24:1537-49
Yilmaz, Atilgan; Kattamuri, Chandramohan; Ozdeslik, Rana N et al. (2016) MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells. Sci Signal 9:ra87
Uzun, Alper; Schuster, Jessica; McGonnigal, Bethany et al. (2016) Targeted Sequencing and Meta-Analysis of Preterm Birth. PLoS One 11:e0155021
Zhang, Jiyong; Klufas, Daniel; Manalo, Karina et al. (2016) HMGB1 Translocation After Ischemia in the Ovine Fetal Brain. J Neuropathol Exp Neurol 75:527-38
Cheng, Shi-Bin; Nakashima, Akitoshi; Sharma, Surendra (2016) Understanding Pre-Eclampsia Using Alzheimer's Etiology: An Intriguing Viewpoint. Am J Reprod Immunol 75:372-81

Showing the most recent 10 out of 164 publications