This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major aims of the Chemistry Core of the Center of Research Excellence in Natural Products Neuroscience are to support the development and submission of R01/R21 grant applications by Junior Faculty from the University of Mississippi. The Core provides expertise for the isolation of the active principles from selected plants, fungi, and marine organisms with CNS activity, elucidate their structures and provide material for in vitro and in vivo pharmacological studies in order to develop new psychotropic drug candidates. The chemistry core also plays an advisory role for individual projects that require expertise in isolation and structure elucidation of secondary metabolites from selected organisms.
The specific aims for the chemistry core as part of their support actvities include: (a) isolation of active secondary metabolites from organisms with CNS activities. (b) structure elucidation of isolated active principles (c) re-isolation or synthesis of 100mg-1g quantities of active components for in vitro and in vivo studies. (d) semi-synthetic modification of lead compounds to generate SAR data and to develop drug candidates.
| Mohamed, Shaymaa M M; Elokely, Khaled M; Bachkeet, Enaam Y et al. (2015) New Glycosides and Trypanocidal Metabolites from Vangueria edulis. Nat Prod Commun 10:1897-900 |
| Radwan, Mohamed M; ElSohly, Mahmoud A; El-Alfy, Abir T et al. (2015) Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa. J Nat Prod 78:1271-6 |
| Tabrizian, Tahmineh; Hataway, Felicia; Murray, David et al. (2015) Prolylcarboxypeptidase gene expression in the heart and kidney: Effects of obesity and diabetes. Cardiovasc Hematol Agents Med Chem 13:113-23 |
| Ahmed, Safwat A; Ross, Samir A; Slade, Desmond et al. (2015) Minor oxygenated cannabinoids from high potency Cannabis sativa L. Phytochemistry 117:194-9 |
| Gómez-Betancur, Isabel; Cortés, Natalie; Benjumea, Dora et al. (2015) Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia. J Ethnopharmacol 165:191-7 |
| Maddineni, Sindhuri; Battu, Sunil Kumar; Morott, Joe et al. (2015) Influence of process and formulation parameters on dissolution and stability characteristics of Kollidon® VA 64 hot-melt extrudates. AAPS PharmSciTech 16:444-54 |
| Morgan, J Brian; Liu, Yang; Coothankandaswamy, Veena et al. (2015) Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Mar Drugs 13:1552-68 |
| Malak, Lourin G; Ibrahim, Mohamed Ali; Bishay, Daoud W et al. (2014) Antileishmanial metabolites from Geosmithia langdonii. J Nat Prod 77:1987-91 |
| Tarawneh, Amer H; León, Francisco; Ibrahim, Mohammed A et al. (2014) Flavanones from Miconia prasina. Phytochem Lett 7:130-132 |
| Chatterjee, Arindam; Cutler, Stephen J; Doerksen, Robert J et al. (2014) Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening. Bioorg Med Chem 22:6409-21 |
Showing the most recent 10 out of 134 publications
