Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases. Signal transduction and molecular trafficking are intertwined in ways that make it impossible to truly understand mechanisms of either in isolation. We propose to create a Center of Biomedical Research Excellence (COBRE) at the University of Nevada, Reno (UNR) in the area of cell biology of signaling across membranes. This COBRE will make significant progress in the emerging fusion of the fields of membrane trafficking and signal transduction by examining how molecular signaling is achieved across membranes, both between cells and between subcellular compartments. Five junior faculty with outstanding research accomplishments will use diverse and uniquely advantageous model systems where critical aspects of signaling and transport functions can be examined by molecular, genetic and structural approaches. The proposed research topics will utilize interdisciplinary approaches in the field of signal transduction and molecular trafficking, including growth factor signaling, regulation of gene expression, nuclear and cytoplasmic transport, secretion, endocytosis, apoptosis, and axon guidance. The proposed COBRE is a comprehensive effort that will integrate high-quality biomedical research and expertise in different departments and colleges at UNR under one theme and program. This will bridge the traditional physical and administrative division between the Colleges of Science and Medicine on the upper and lower campus at UNR, and foster interactions that lead to synergism and enhanced biomedical research capacity. The COBRE will provide an efficient mentoring program for junior faculty that will expand already existing training programs at UNR, and support the research of selected young faculty by teaming with clinical mentors and consultants to establish disease focus. The COBRE will provide enhanced infrastructure and technical support for Nevada's new generation of biomedical researchers with truly outstanding credentials and promise for major achievements in biomedical research.

Public Health Relevance

Signaling across cell membranes is fundamentally important for normal cellular function and for understanding many diseases, ranging from cancer (abnormal proliferation) to neurodegenerative diseases (abnormal trophic signaling). The common and ultimate overall research goal of this proposal is to understand, and eventually manipulate, fundamental processes of signaling in cell biology that are relevant for human disorders, including cancer, immunological and neurological diseases and enteric malformations.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
1P20RR024210-01A2
Application #
7826050
Study Section
Special Emphasis Panel (ZRR1-RI-3 (01))
Program Officer
Douthard, Regine
Project Start
2011-09-15
Project End
2016-07-31
Budget Start
2011-09-15
Budget End
2012-07-31
Support Year
1
Fiscal Year
2011
Total Cost
$2,142,276
Indirect Cost
Name
University of Nevada Reno
Department
Physiology
Type
Schools of Medicine
DUNS #
146515460
City
Reno
State
NV
Country
United States
Zip Code
89557
Li, Li-Jun; Hu, Rong; Lujan, Brendan et al. (2016) Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-Containing NMDA Receptors. Front Mol Neurosci 9:102
Moreno-Bravo, Juan A; Martinez-Lopez, Jesus E; Madrigal, M Pilar et al. (2016) Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion. Brain Struct Funct 221:665-78
Hu, Rong; Chen, Juan; Lujan, Brendan et al. (2016) Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection. Sci Rep 6:34459
Bjorke, Brielle; Shoja-Taheri, Farnaz; Kim, Minkyung et al. (2016) Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. Neural Dev 11:18
Shoja-Taheri, Farnaz; DeMarco, Arielle; Mastick, Grant S (2015) Netrin1-DCC-Mediated Attraction Guides Post-Crossing Commissural Axons in the Hindbrain. J Neurosci 35:11707-18
Dascenco, Dan; Erfurth, Maria-Luise; Izadifar, Azadeh et al. (2015) Slit and Receptor Tyrosine Phosphatase 69D Confer Spatial Specificity to Axon Branching via Dscam1. Cell 162:1140-54
McDowell, Stephen C; López-Marqués, Rosa L; Cohen, Taylor et al. (2015) Loss of the Arabidopsis thaliana P4-ATPases ALA6 and ALA7 impairs pollen fitness and alters the pollen tube plasma membrane. Front Plant Sci 6:197
Snodgrass, Casey J; Burnham-Marusich, Amanda R; Meteer, John C et al. (2015) Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells. Glycobiology 25:403-11
Kim, Minkyung; Farmer, W Todd; Bjorke, Brielle et al. (2014) Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion. Neural Dev 9:17
García-Peña, Claudia M; Kim, Minkyung; Frade-Pérez, Daniela et al. (2014) Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding. Front Neuroanat 8:43

Showing the most recent 10 out of 25 publications