This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise.
Biological changes induced by oxidative stress are associated with numerous human pathologies. By studying how such stresses impact cells through macromolecular damage and signaling pathways will be important in understanding the etiology and therapeutic approaches to diseases such as cancer, diabetes, neurodegenerative and cardiovascular disorders as well as pathologies linked with aging.
|Viglianti, Benjamin L; Wong, Ka Kit; Wimer, Stephanie M et al. (2017) Effect of hyperglycemia on brain and liver 18F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging. Biomed Pharmacother 88:1038-1045|
|Ye, Zhi-Wei; Zhang, Jie; Ancrum, Tiffany et al. (2017) Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response. Antioxid Redox Signal 26:247-261|
|Hedges, David M; Obray, J Daniel; Yorgason, Jordan T et al. (2017) Methamphetamine Induces Dopamine Release in the Nucleus Accumbens Through a Sigma Receptor-Mediated Pathway. Neuropsychopharmacology :|
|Mazza, Alberto; Lenti, Salvatore; Schiavon, Laura et al. (2017) Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population. Biomed Pharmacother 86:590-594|
|Nimitvilai, Sudarat; Uys, Joachim D; Woodward, John J et al. (2017) Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. J Neurosci 37:3646-3660|
|Oda, Caroline Mari Ramos; Fernandes, Renata Salgado; de Araújo Lopes, Sávia Caldeira et al. (2017) Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering. Biomed Pharmacother 89:268-275|
|Pulkoski-Gross, Michael J; Uys, Joachim D; Orr-Gandy, K Alexa et al. (2017) Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat 130:47-56|
|Davis Jr, Warren; Tew, Kenneth D (2017) ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target. Biochem Pharmacol :|
|Ferreira, Carolina de Aguiar; Fuscaldi, Leonardo Lima; Townsend, Danyelle M et al. (2017) Radiolabeled bombesin derivatives for preclinical oncological imaging. Biomed Pharmacother 87:58-72|
|Zane, Mariangela; Parello, Carmelo; Pennelli, Gianmaria et al. (2017) Estrogen and thyroid cancer is a stem affair: A preliminary study. Biomed Pharmacother 85:399-411|
Showing the most recent 10 out of 43 publications