Fostering research directed toward the presymptomatic to early AD spectrum, the Oregon Alzheimer's Disease Center (OADC) supports an array of distinct investigations ranging from CSF proteomics to real-time change detection using automated in-home assessments. In this highly interactive environment, the OADC Data Management and Statistics Core (DMSC) ensures the integrity of the data coming from multiple sources and provides prompt distribution of user-friendly data as well as reliable and appropriate analyses and thoughtful consultations for a wide-range of researchers. In order to maximize the likelihood of successful accomplishment of the data processing and sharing functions of the OADC, the DMSC was established as a separate Core in our initial application funded in 1990. It has maintained Core status throughout the history of the OADC. Within the DMSC team, the Database Systems Manager together with the Data Manager maintain an extensible relational database, select and implement database management software, represent data structures, specify and organize data flow, construct detailed """"""""error-check"""""""" programs, develop/implement data checking and cleaning procedures, and provide for data entry and access, as well as information distribution. DMSC biostatisticians are actively involved in the design and analysis of OADC studies and proposals and have established their own research areas of emphasis collaborating with all OADC Cores and investigators at other centers. All data is provided with strict confidentiality and security measures in place, adhering to all Health Insurance Portability and Accountability Act (HIPAA) and IRB regulations. With these guidelines in place, customized longitudinal data, data management and statistical consulting to research projects and cores of the OADC, as well as the National Alzheimer's Coordinating Center (NACC) and other interested investigators are provided.

Public Health Relevance

The OADC Data Core provides key data management and biostatistical services to ensure high quality data and thoughtful data analysis and study design. The privacy protected and secure data is intended to be widely used and shared. The resulting research findings will lead to improvements in clinical care and public health planning, and ultimately to finding effective treatments for cognitive impairment and dementia.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG008017-23S1
Application #
8514261
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
1997-01-01
Project End
2014-03-31
Budget Start
2012-05-01
Budget End
2013-03-31
Support Year
23
Fiscal Year
2012
Total Cost
$22,989
Indirect Cost
$8,061
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Alosco, Michael L; Duskin, Jonathan; Besser, Lilah M et al. (2017) Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer's Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer's Coordinating Center Data Set. J Alzheimers Dis 57:953-968
Kim, Julia; Schweizer, Tom A; Fischer, Corinne E et al. (2017) The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer's Disease. J Alzheimers Dis 55:381-389
Pandya, Seema Y; Lacritz, Laura H; Weiner, Myron F et al. (2017) Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition. Dement Geriatr Cogn Disord 43:204-214
Mattos, Meghan K; Snitz, Beth E; Lingler, Jennifer H et al. (2017) Older Rural- and Urban-Dwelling Appalachian Adults With Mild Cognitive Impairment. J Rural Health 33:208-216
Jun, Gyungah R; Chung, Jaeyoon; Mez, Jesse et al. (2017) Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement 13:727-738
Wardzala, Casia; Murchison, Charles; Loftis, Jennifer M et al. (2017) Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians. Psychopharmacology (Berl) :
Jutkowitz, Eric; MacLehose, Richard F; Gaugler, Joseph E et al. (2017) Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients. J Gerontol A Biol Sci Med Sci 72:251-258
Sims, Rebecca (see original citation for additional authors) (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 49:1373-1384
Dodge, Hiroko H; Zhu, Jian; Woltjer, Randy et al. (2017) Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease. Alzheimers Dement 13:613-623
Boise, Linda; Hinton, Ladson; Rosen, Howard J et al. (2017) Willingness to Be a Brain Donor: A Survey of Research Volunteers From 4 Racial/Ethnic Groups. Alzheimer Dis Assoc Disord 31:135-140

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