The Neuropathology (NP) Core of this ADCC will provide for post-mortem diagnoses on patients and control subjects enrolled in the clinical core and on other well-documented AD cases and controls. The protocols used by the NP aim to be state of the art and consistent with 21st century brain banking procedures, which is essential to met the increasingly sophisticated needs of the AD research community {3922, 3921, 3920, 3919, 3918}. The tissue of the NP core is banked and distributed for research purposes as determined by the Tissue Utilization Committee, while protecting the privacy of research subjects. Part of this NP core and unchanged from the prior grant period, is a Morphometric Component performed at the Institute for Basic Research (IBR) on Staten Island. The Morphometric Component of this core is essential for the careful characterization of AD and control brain tissue in terms of the volume of different brain structures, number of neurons, glial cells, amyloid load and neurons with neurofibrillary change. This information can then be used for precise clinico-pathological correlation.
The Specific Aims of this Neuropathology Core are: 1 .To conduct thorough postmortem examinations on NYU ADCC patients (N=25-30/yr from NYU) using the NIA-Reagan Institute Working Group criteria for the diagnosis of AD. 2.To maintain a bank of unfixed frozen and fixed tissue from the ADCC control and patients with AD or other dementing neurodegenerative conditions. 3.To provide tissue from control brains, AD and other neurodegenerative conditions to AD and prion researchers within and outside this ADCC in order to augment clinical and basic research on dementia. 4.To conduct morphometric studies on AD to establish better clinical neuropathological correlation, in particular to document the progression of the earlier stages of AD pathology. 5.To conduct anatomic and pathologic correlation with in vivo and post mortem MR scans in collaboration with the Neuroimaging Core. 6.To collaborate in the research efforts of the other cores and projects of the ADCC, as well as providing advice and facilities to investigators within and outside the ADCC who seek to conduct morphometric, immunohistochemical of demented and control patients using post-mortem tissue.

Public Health Relevance

The NP core functions to provide essential neuropathological and morphometric characterization of patients who are followed in the clinical core, to allow for clinico-pathological correlations. In addition, it serves to provide tissue for numerous NIH funded AD and prion researchers. The NP core also serves as a resources for peforming studies on AD human and mouse model tissue.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-4)
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New York University
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Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204
Tripodis, Yorghos; Alosco, Michael L; Zirogiannis, Nikolaos et al. (2017) The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer's Disease Dementia. J Alzheimers Dis 59:251-263
Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2017) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement 13:654-662
Jutkowitz, Eric; Kane, Robert L; Gaugler, Joseph E et al. (2017) Societal and Family Lifetime Cost of Dementia: Implications for Policy. J Am Geriatr Soc 65:2169-2175
Pankiewicz, Joanna E; Baquero-Buitrago, Jairo; Sanchez, Sandrine et al. (2017) APOE Genotype Differentially Modulates Effects of Anti-A?, Passive Immunization in APP Transgenic Mice. Mol Neurodegener 12:12
Moheb, Negar; Mendez, Mario F; Kremen, Sarah A et al. (2017) Executive Dysfunction and Behavioral Symptoms Are Associated with Deficits in Instrumental Activities of Daily Living in Frontotemporal Dementia. Dement Geriatr Cogn Disord 43:89-99
Wegiel, Jarek; Flory, Michael; Kaczmarski, Wojciech et al. (2017) Partial Agenesis and Hypoplasia of the Corpus Callosum in Idiopathic Autism. J Neuropathol Exp Neurol 76:225-237
Cedernaes, Jonathan; Osorio, Ricardo S; Varga, Andrew W et al. (2017) Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease. Sleep Med Rev 31:102-111
Monsell, Sarah E; Mock, Charles; Fardo, David W et al. (2017) Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. Alzheimer Dis Assoc Disord 31:232-238
Drummond, Eleanor; Nayak, Shruti; Faustin, Arline et al. (2017) Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease. Acta Neuropathol 133:933-954

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