Since 1990, the ADC at NYU has been providing core resources and support to a comprehensive, multidisciplinary research program on aging and AD that spans basic through psychosocial research. The main scientific goal of the ADC is to facilitate and enhance research that will lead to early diagnosis and prevention. Over the next 5-years, core resources will be used to study the transition from normal aging to mild cognitive impairment (MCI) and early AD. In addition to NYU SoM, investigators at the Nathan Kline Institute (NKI), the NYS Institute for Basic Research (IBR), and other New York City area facilities are also participating. Patients with AD and related disorders, subjects with MCI, and cognitively normal subjects are studied longitudinally through postmortem. A Director and Associate Leaders who serve on an Executive Committee and an External Advisory Committee supervise the ADC. Standard ADC cores supported consist of Administrative, Clinical, Neuropathology, Data Management and Education Cores. In addition, Neuroimaging and Caregiver Cores significantly strengthen the research contributions of ADC investigators. The Clinical Core includes a Satellite Multicultural Program focusing on minority recruitment, and an ADC Biorepository (a joint effort of the Clinical, Neuroimaging and Neuropathology Cores) stores and provides investigators with CSF, blood and postmortem brain tissue samples. The Neuropathology Core includes a morphometry component at IBR. Each year, the ADC directly supports several pilot studies, and provides core resources (subjects;clinical, neuroimaging and psychosocial data;blood, CSF and brain tissue) to extensive current research receiving primary support from NIH and other sources. The extensive multidisciplinary research utilizing the ADC has been strengthened by the creation of a Center of Excellence on Brain Aging. There is also extensive collaboration with other ADC's and national consortia, and data from the NYU ADC is shared with the National Alzheimer's Coordinating Center (NACC) and with numerous collaborating investigators. The ADC has made and will continue to make substantial contributions toward eliminating the problem of AD.

Public Health Relevance

There are more than 5-million AD patients in the U.S, a number that will triple in the next few decades due to the dramatic expansion of the elderly population. This neurodegenerative disease has a devastating impact on patients and families and on the healthcare system. In supporting research on early detection and prevention, the ADC will help reduce and eventually eliminate this major public health problem.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG008051-24
Application #
8469371
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (J1))
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2015-04-30
Budget Start
2013-06-15
Budget End
2014-04-30
Support Year
24
Fiscal Year
2013
Total Cost
$1,704,120
Indirect Cost
$673,661
Name
New York University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Galvin, James E; Tolea, Magdalena I; George, Nika et al. (2014) Public-private partnerships improve health outcomes in individuals with early stage Alzheimer's disease. Clin Interv Aging 9:621-30
Grill, Joshua D; Galvin, James E (2014) Facilitating Alzheimer disease research recruitment. Alzheimer Dis Assoc Disord 28:1-8
Salloway, Stephen; Sperling, Reisa; Fox, Nick C et al. (2014) Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med 370:322-33
Mosconi, Lisa; Murray, John; Tsui, Wai H et al. (2014) Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology 82:752-60
Sabharwal, Priyanka; Wisniewski, Thomas (2014) Novel immunological approaches for the treatment of Alzheimer's disease. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi 14:139-151
Zhang, Ying; Shi, Zhihong; Liu, Mengyuan et al. (2014) Prevalence of cognitive impairment no dementia in a rural area of Northern China. Neuroepidemiology 42:197-203
Butler, Tracy; Zaborszky, Laszlo; Pirraglia, Elizabeth et al. (2014) Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology. Neuroimage 97:245-51
Reisberg, Barry; Monteiro, Isabel; Torossian, Carol et al. (2014) The BEHAVE-AD assessment system: a perspective, a commentary on new findings, and a historical review. Dement Geriatr Cogn Disord 38:89-146
Iulita, M Florencia; Do Carmo, Sonia; Ower, Alison K et al. (2014) Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain 137:860-72
Jessen, Frank; Amariglio, Rebecca E; van Boxtel, Martin et al. (2014) A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement 10:844-52

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