The objective of this Administrative Core (Core A) is to support the mission of the University of Pennsylvania (Penn) Alzheimer's Disease (AD) Core Center (ADCC) by facilitating efforts to increase research and understanding of AD and related disorders as well as mild cognitive impairment (MCI) and healthy aging at and beyond Penn. Core A also sets the direction ofthe ADCC, guides development of its programs, promotes interactions of its investigators with National Institute on Aging (NIA) funded AD Centers (ADCs), the National AD Coordinating Center (NACC), the AD Cooperative Study (ADCS), the AD Education and Referral (ADEAR) Center, the AD Neuroimaging Initiative (ADNI), the AD Genetics Consortium (ADGC) and other related NIH and public/private agency supported initiatives focused on AD and related disorders. Core A will accomplish these goals through five highly effective mechanisms. First, Core A provides fiscal and administrative oversight of the ADCC, and the ADCC Executive Committee meets regularly to review ADCC activities and address issues as they arise. Second, Pilot grant applications are solicited annually, and the ADCC Pilot Review Committee identifies 2 meritorious Pilots for funding each year by the ADCC as well as 1-3 additional Pilots funded by the Penn Institute on Aging (lOA) which partners with the ADCC in this Pilot program. Third, Core A organizes annual reviews ofthe Penn ADCC by the ADCC External Advisory Committee. Fourth, Core A facilitates participation of ADCC investigators in annual Penn-wide retreats held by the lOA and the Center for Neurodegenerative Disease Research (CNDR) for students, postdoctoral fellows and faculty from a wide range of disciplines in neuroscience and aging. Finally, Core A promotes interactions of the Penn ADCC with NACC, ADCS, ADEAR, ADNI, ADGC and other ADCs in education and research initiatives. Thus, Core A provides a clearly delineated administrative structure that enables the Penn ADCC to increase the quality and quantity of clinical and basic research as well as educational activities on AD and related disorders as well as MCI and normal aging at and beyond Penn.
;Administrative Core A is highly relevant to the continued success of the Penn ADCC because it exercises fiscal and administrative oversight over this Center, facilitates interactions among ADCC investigators to accomplish the research conducted in programs linked to the Penn ADCC which is the foundational neurodegenerative disease program that has spawned/enabled other neurodegenerative disease research programs at Penn. Finally, Core A coordinates and integrates activities ofthe Cores, and provides mechanisms to advise the Principal Investigator and Core Leaders of this PPG on their progress towards accomplishing the goals of NIA funded ADCCs.
|Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161|
|Stites, Shana D; Harkins, Kristin; Rubright, Jonathan D et al. (2018) Relationships Between Cognitive Complaints and Quality of Life in Older Adults With Mild Cognitive Impairment, Mild Alzheimer Disease Dementia, and Normal Cognition. Alzheimer Dis Assoc Disord 32:276-283|
|Hansson, Oskar; Seibyl, John; Stomrud, Erik et al. (2018) CSF biomarkers of Alzheimer's disease concord with amyloid-? PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts. Alzheimers Dement 14:1470-1481|
|Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487|
|Barupal, Dinesh Kumar; Fan, Sili; Wancewicz, Benjamin et al. (2018) Generation and quality control of lipidomics data for the alzheimer's disease neuroimaging initiative cohort. Sci Data 5:180263|
|Lleó, Alberto; Irwin, David J; Illán-Gala, Ignacio et al. (2018) A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes. JAMA Neurol 75:738-745|
|Xie, Long; Das, Sandhitsu R; Wisse, Laura E M et al. (2018) Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex. J Alzheimers Dis 62:85-92|
|Martini-Stoica, Heidi; Cole, Allysa L; Swartzlander, Daniel B et al. (2018) TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J Exp Med 215:2355-2377|
|He, Zhuohao; Guo, Jing L; McBride, Jennifer D et al. (2018) Amyloid-? plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nat Med 24:29-38|
|Phillips, Jeffrey S; Das, Sandhitsu R; McMillan, Corey T et al. (2018) Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease. Hum Brain Mapp 39:691-708|
Showing the most recent 10 out of 720 publications