The Neuropathology Core (NPC) supports the clinical and research missions of the UCD ADC by providing (1) expert neuropathological (NP) analysis;and (2) well-preserved brain tissue, along with blood and DNA samples from the clinically well-characterized participants of our longitudinal cohort. In addition, the NPC plays an important role in bolstering basic and translational research on AD and related disorders by providing tissue samples, NP techniques, and NP tools. The UCD NPC has established expertise in postmortem NP analysis, with a special focus on assessment of vascular brain injury. The NPC works closely with the Clinical Core and the Neuroimaging Core to provide clinico-imaging-pathological correlation. The NPC works closely with the Data Management and Statistics Core to incorporate the NP data and tissue information to the web-based UCD ADC database, facilitating research. In collaboration with the Education and Information Transfer Core, the NPC promotes consenting to autopsy by our study subjects, and the use of the NPC resource for research. In the current funding period, we have accomplished all the proposed Aims. We have streamlined our brain and tissue procurement and processing procedures, and obtained more "research-grade" brain samples. We have collected and banked serum, plasma, and peripheral blood DNA from over 750 individuals participating in UCD ADC-sponsored research protocols. We have made substantial progress in obtaining minority autopsies. We have also developed new research tools such as tissue microarray and multiplex quantification method. Due to our enhanced infrastructure for research, the UCD NPC has become an essential player in the overarching UCD ADC research goal and have contributed to several multi-center projects involving sharing of neuropathological data and samples. Furthermore, there has been a substantial increase in the use of our biological samples by investigators within UCD and outside the ADC. and as a result we supported numerous grants and papers. In this reapplication. we propose to continue all the current aims, with new perspectives and opportunities building on the progress achieved during the current grant cycle.
By investigating the heterogeneity of brain injury within a diverse study cohort recruited by the Clinical Core, the NPC provides the final diagnosis and an essential set of NP data useful for validating biomarkers and diagnostic criteria. The NPC is also an essential resource for many research projects on neurodegenerative disorders, providing biological specimens, NP techniques, and NP tools.
|Rueda, Alicia D; Lau, Karen M; Saito, Naomi et al. (2015) Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease. Alzheimers Dement 11:1080-9|
|Caroli, Anna; Prestia, Annapaola; Wade, Sara et al. (2015) Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI. Alzheimer Dis Assoc Disord 29:101-9|
|Mah, Linda; Binns, Malcolm A; Steffens, David C et al. (2015) Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. Am J Geriatr Psychiatry 23:466-76|
|Dmitrieva, Natalia O; Fyffe, Denise; Mukherjee, Shubhabrata et al. (2015) Demographic characteristics do not decrease the utility of depressive symptoms assessments: examining the practical impact of item bias in four heterogeneous samples of older adults. Int J Geriatr Psychiatry 30:88-96|
|Sisco, Shannon; Gross, Alden L; Shih, Regina A et al. (2015) The role of early-life educational quality and literacy in explaining racial disparities in cognition in late life. J Gerontol B Psychol Sci Soc Sci 70:557-67|
|Bertens, Daniela; Knol, Dirk L; Scheltens, Philip et al. (2015) Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease. Alzheimers Dement 11:511-22|
|Melrose, Rebecca J; Brewster, Paul; Marquine, María J et al. (2015) Early life development in a multiethnic sample and the relation to late life cognition. J Gerontol B Psychol Sci Soc Sci 70:519-31|
|Teng, Edmond; Chow, Nicole; Hwang, Kristy S et al. (2015) Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort. Dement Geriatr Cogn Disord 39:154-66|
|Epstein, Noam U; Guo, Rong; Farlow, Martin R et al. (2014) Medication for Alzheimer's disease and associated fall hazard: a retrospective cohort study from the Alzheimer's Disease Neuroimaging Initiative. Drugs Aging 31:125-9|
|Qiu, Yue; Li, Liang; Zhou, Tian-yan et al. (2014) Alzheimer's disease progression model based on integrated biomarkers and clinical measures. Acta Pharmacol Sin 35:1111-20|
Showing the most recent 10 out of 579 publications