The DMSC provides centralized resources in providing data management and statistical support to IADC investigators. We had developed database systems to capture clinical, neuropathological and genetic data collected in all IADC cores. The DMSC will provide timely and adequate support for the IADC to implement NIA mandated Uniform Data Set (UDS). DMSC data managers will work with Clinical Core investigators and staff to ensure that all information specified in the UDS are accurately collected according to NACC guideline. We developed database applications to capture data collected in the UDS, and ensure accurate data entry and transfer to the National Alzheimer Coordinating Center (NACC). In addition, DMSC data managers will develop and maintain an integrated and secure data system to facilitate data entry, quality control, patient and specimen tracking, data access and provide safeguards to patient-identifying information to comply with federal regulations. The DMSC will provide quality data to support collaborative research initiatives at the national level as well as specific demands from IADC investigators. The DMSC will continue to support faculty members from the Division of Biostatistics at Indiana University School of Medicine who have been involved in both collaborative AD research and independent methodological research in developing new statistical methods applicable in AD research.
The specific aims of the Data Management and Statistics Core are: to develop and maintain an integrated database for data collected in the Clinical and Neuropathology Cores;to continue to provide statistical leadership and support to IADC and associated investigators on dementia projects;to develop and maintain a web-based data query system on the IADC web, and to assist the Education Core in developing databases for program evaluation, subject recruitment and tracking..

Public Health Relevance

It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
United States
Zip Code
Chapman, Kimberly R; Bing-Canar, Hanaan; Alosco, Michael L et al. (2016) Mini Mental State Examination and Logical Memory scores for entry into Alzheimer's disease trials. Alzheimers Res Ther 8:9
Kovacs, Gabor G; Ferrer, Isidro; Grinberg, Lea T et al. (2016) Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol 131:87-102
Nho, Kwangsik; Saykin, Andrew J (2016) Reply. Ann Neurol 79:335
Lahiri, Debomoy K; Maloney, Bryan; Bayon, Baindu L et al. (2016) Transgenerational latent early-life associated regulation unites environment and genetics across generations. Epigenomics 8:373-87
Ridge, Perry G; Hoyt, Kaitlyn B; Boehme, Kevin et al. (2016) Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging 41:200.e13-20
Green, Colin; Zhang, Shenqiu (2016) Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model. Alzheimers Dement 12:776-85
Nudelman, Kelly N H; McDonald, Brenna C; Wang, Yang et al. (2016) Cerebral Perfusion and Gray Matter Changes Associated With Chemotherapy-Induced Peripheral Neuropathy. J Clin Oncol 34:677-83
Ringman, John M; Monsell, Sarah; Ng, Denise W et al. (2016) Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. J Neuropathol Exp Neurol 75:284-90
Li, Wei; Risacher, Shannon L; McAllister, Thomas W et al. (2016) Erratum to: Traumatic brain injury and age at onset of cognitive impairment in older adults. J Neurol 263:1286
Jun, G; Ibrahim-Verbaas, C A; Vronskaya, M et al. (2016) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry 21:108-17

Showing the most recent 10 out of 451 publications