The DMSC provides centralized resources in providing data management and statistical support to IADC investigators. We had developed database systems to capture clinical, neuropathological and genetic data collected in all IADC cores. The DMSC will provide timely and adequate support for the IADC to implement NIA mandated Uniform Data Set (UDS). DMSC data managers will work with Clinical Core investigators and staff to ensure that all information specified in the UDS are accurately collected according to NACC guideline. We developed database applications to capture data collected in the UDS, and ensure accurate data entry and transfer to the National Alzheimer Coordinating Center (NACC). In addition, DMSC data managers will develop and maintain an integrated and secure data system to facilitate data entry, quality control, patient and specimen tracking, data access and provide safeguards to patient-identifying information to comply with federal regulations. The DMSC will provide quality data to support collaborative research initiatives at the national level as well as specific demands from IADC investigators. The DMSC will continue to support faculty members from the Division of Biostatistics at Indiana University School of Medicine who have been involved in both collaborative AD research and independent methodological research in developing new statistical methods applicable in AD research.
The specific aims of the Data Management and Statistics Core are: to develop and maintain an integrated database for data collected in the Clinical and Neuropathology Cores;to continue to provide statistical leadership and support to IADC and associated investigators on dementia projects;to develop and maintain a web-based data query system on the IADC web, and to assist the Education Core in developing databases for program evaluation, subject recruitment and tracking..
It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.
|Li, Huang; Fang, Shiaofen; Contreras, Joey A et al. (2017) Brain explorer for connectomic analysis. Brain Inform 4:253-269|
|Yao, Xiaohui; Yan, Jingwen; Ginda, Michael et al. (2017) Mapping longitudinal scientific progress, collaboration and impact of the Alzheimer's disease neuroimaging initiative. PLoS One 12:e0186095|
|Sano, Mary; Zhu, Carolyn W; Grossman, Hillel et al. (2017) Longitudinal Cognitive Profiles in Diabetes: Results From the National Alzheimer's Coordinating Center's Uniform Data. J Am Geriatr Soc 65:2198-2204|
|Sokolow, Sophie; Li, Xiaohui; Chen, Lucia et al. (2017) Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment. J Alzheimers Dis 56:229-237|
|Tripodis, Yorghos; Alosco, Michael L; Zirogiannis, Nikolaos et al. (2017) The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer's Disease Dementia. J Alzheimers Dis 59:251-263|
|Jefferson-George, Kyra S; Wolk, David A; Lee, Edward B et al. (2017) Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimers Dement 13:1048-1053|
|Brenowitz, Willa D; Hubbard, Rebecca A; Keene, C Dirk et al. (2017) Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement 13:654-662|
|Brosch, Jared R; Farlow, Martin R; Risacher, Shannon L et al. (2017) Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials. Neurotherapeutics 14:62-68|
|Jutkowitz, Eric; Kane, Robert L; Gaugler, Joseph E et al. (2017) Societal and Family Lifetime Cost of Dementia: Implications for Policy. J Am Geriatr Soc 65:2169-2175|
|Garringer, Holly J; Sammeta, Neeraja; Oblak, Adrian et al. (2017) Amyloid and intracellular accumulation of BRI2. Neurobiol Aging 52:90-97|
Showing the most recent 10 out of 531 publications