The Neuroimaging Core (NIC) is the newest component of the IADC and was funded by a competitive supplement in May 2009. Several scientific themes guide the NIC: (1) Imaging as an in-vivo window to neuropathological processes and (2) as a biomarker for early detection and treatment response;(3) The integration of imaging and genetics is an important new direction with great promise for assessing candidate genes/pathways and discovery of new molecular mechanisms;(4) Translational imaging research with common methodology across clinical studies and animal models;and (5) The need for transdisciplinary collaborative teams and educational opportunities. The overarching goal is to support advanced neuroimaging technology and scientific collaboration for clinical and translational research studies within the Indiana ADC and to serve as a regional and national resource.
Specific Aims : (1) Support currently funded research in the IADC, IU Center for Aging Research, and related programs that currently employs or could benefit from advanced neuroimaging;(2) Expand transdisciplinary regional neuroscience research using advanced neuroimaging tools to study disease mechanisms and treatments for neurodegeneration;(3) Support and collaborate with major national and intemationai AD-related research consortia using neuroimaging and genetics methods;(4) Provide standardized, state-of-the-art neuroimaging acquisition and analysis protocols; and (5) Provide transdisciplinary educational opportunities in neuroimaging and genetics of AD and other degenerative disorders for basic and clinical scientists at all levels, as well as dissemination to the community. The NIC will expand the scientific value of outstanding research programs on campus as well as contribute to national initiatives on dementia (e.g. ADNI, DIAN and ADGC). Examples of IADC related projects that will greatly benefit from support from the NIC include multiple family studies of hereditary dementias and related transgenic animal models developed by IADC investigators, the Indianapolis Healthy Aging Brain Center and African-American Health and Aging Cohort, several MCI related ROI projects, and other innovative programs of the Center for Aging Research. The NIC will work closely with other IADC cores to foster research employing advanced brain imaging that will create important new knowledge regarding dementia.
It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.
|Ramanan, V K; Nho, K; Shen, L et al. (2015) FASTKD2 is associated with memory and hippocampal structure in older adults. Mol Psychiatry 20:1197-204|
|Austrom, Mary Guerriero; Geros, Kristin N; Hemmerlein, Kimberly et al. (2015) Use of a multiparty web based videoconference support group for family caregivers: Innovative practice. Dementia (London) 14:682-90|
|De, Wang; Wang, Yang; Nie, Feiping et al. (2014) Human connectome module pattern detection using a new multi-graph MinMax cut model. Med Image Comput Comput Assist Interv 17:313-20|
|Ramanan, V K; Risacher, S L; Nho, K et al. (2014) APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Mol Psychiatry 19:351-7|
|Yan, Jingwen; Du, Lei; Kim, Sungeun et al. (2014) Transcriptome-guided amyloid imaging genetic analysis via a novel structured sparse learning algorithm. Bioinformatics 30:i564-71|
|Boespflug, Erin L; Storrs, Judd; Sadat-Hossieny, Sara et al. (2014) Full diffusion characterization implicates regionally disparate neuropathology in mild cognitive impairment. Brain Struct Funct 219:367-79|
|Cheng, Yibin; Jin, Yinlong; Unverzagt, Frederick W et al. (2014) The relationship between cholesterol and cognitive function is homocysteine-dependent. Clin Interv Aging 9:1823-9|
|Oblak, Adrian L; Hagen, Matthew C; Sweadner, Kathleen J et al. (2014) Rapid-onset dystonia-parkinsonism associated with the I758S mutation of the ATP1A3 gene: a neuropathologic and neuroanatomical study of four siblings. Acta Neuropathol 128:81-98|
|Nuytemans, Karen; Inchausti, Vanessa; Beecham, Gary W et al. (2014) Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Mov Disord 29:827-30|
|Jessen, Frank; Amariglio, Rebecca E; van Boxtel, Martin et al. (2014) A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement 10:844-52|
Showing the most recent 10 out of 255 publications