The Indiana Alzheimer Disease Center (IADC) is established on the campus of Indiana University School of Medicine. It is comprised of six cores: Administrative Core, Clinical Core, Data Management and Statistics Core, Neuropathology Core, Education and Information Transfer Core and Neuroimaging Core. The mission of the IADC is: 1) to support and carry out research on Alzheimer disease (AD) and other neurodegenerative dementias, 2) to serve as shared research resources that will facilitate research in AD and other dementias, 3)distinguish them from the processes of normal brain aging and mild cognitive impairment (MCI), 4) provide a platform for training, 5) develop novel techniques and methodologies, and 6) translate these research findings into better diagnostic, prevention and treatment strategies. The focus of the IADC is on behavioral neurology, clinicopathological correlations, biochemistry, and genetics of AD, frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17), Gerstmann-Strussler-Scheinker disease (GSS), Parkinson disease and other hereditary diseases associated with abnormal protein accumulation.

Public Health Relevance

It is estimated that as many as 5 million Americans have AD. The Indiana Alzheimer Disease Center provides an environment and resources directed towards fostering and coordinating research and educational activities on AD and other dementing illnesses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
3P30AG010133-24S1
Application #
8793000
Study Section
Neuroscience of Aging Review Committee (NIA)
Program Officer
Silverberg, Nina B
Project Start
1997-07-15
Project End
2016-06-30
Budget Start
2014-09-30
Budget End
2015-06-30
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Li, Wei; Risacher, Shannon L; Gao, Sujuan et al. (2018) Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid ?1-42 in Alzheimer's Disease Neuroimaging Initiative participants. Alzheimers Dement (Amst) 10:94-98
Wang, Xiaoqian; Chen, Hong; Yan, Jingwen et al. (2018) Quantitative trait loci identification for brain endophenotypes via new additive model with random networks. Bioinformatics 34:i866-i874
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17
Hadjichrysanthou, Christoforos; McRae-McKee, Kevin; Evans, Stephanie et al. (2018) Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies. J Alzheimers Dis 66:587-600
Wilmoth, Kristin; LoBue, Christian; Clem, Matthew A et al. (2018) Consistency of traumatic brain injury reporting in older adults with and without cognitive impairment. Clin Neuropsychol 32:524-529
Risacher, Shannon L; Farlow, Martin R; Bateman, Daniel R et al. (2018) Detection of tau in Gerstmann-Sträussler-Scheinker disease (PRNP F198S) by [18F]Flortaucipir PET. Acta Neuropathol Commun 6:114
Ting, Simon Kang Seng; Foo, Heidi; Chia, Pei Shi et al. (2018) Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. J Neuropsychiatry Clin Neurosci 30:31-37
Hanfelt, John J; Peng, Limin; Goldstein, Felicia C et al. (2018) Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center. Neurobiol Dis 117:62-71
Zhou, Zilu; Wang, Weixin; Wang, Li-San et al. (2018) Integrative DNA copy number detection and genotyping from sequencing and array-based platforms. Bioinformatics 34:2349-2355
Ridge, Perry G; Wadsworth, Mark E; Miller, Justin B et al. (2018) Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping. Alzheimers Dement 14:514-519

Showing the most recent 10 out of 604 publications