The central theme of the UT Southwestern ADC is that vascular and inflammatory risk factors in elderly individuals influence the course of AD, MCI and FTLD, and that such factors constitute endophenotypes. A requirement of such endophenotypes is that they be measurable by quantitative psychometric, physiologic, neuroimaging, or biochemical methods. Over the next 5 years, the Clinical Core will carry out studies aimed at developing methods to study these vascular and inflammatory endophenotypes and assess their contribution to AD, MCI, FTLD and normal aging. Our specific hypothesis is that the age of onset and rate of progression of patients presenting with early-stage AD (including MCI) and FTLD are related to the presence of vascular and inflammatory endophenotypes. This hypothesis reflects the interests of Center investigators as well as the expertise of other investigators at UT Southwestern Medical Center. While this theme is our focus, the UTSW ADC also functions the academic home of dementia-related research on campus, and works to foster and support investigator-initiated research projects at UTSW and related institutions. This includes creating a forum for interactions among scientists from various departments and facilitating research across disciplines. The UTSW ADC runs a highly successful Pilot Grants Program, which has attracted promising young investigators to the field who have gone on to win independent extramural funding. Finally, the UTSW ADC continues its productive participation by UT Southwestern in multi-institutional collaborative studies.

Public Health Relevance

The development of successful therapies for Alzheimer's disease (AD) will require a thorough understanding of the pathologic mechanisms that contribute to neurodegeneration. Data from epidemiologic and observational studies indicates that vascular and inflammatory pathology contributes to AD. The goal of the UTSW ADC is to identify biomarkers of vascular and inflammatory pathology that will be useful for selection of participants in clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG012300-19
Application #
8501177
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$259,462
Indirect Cost
$96,279
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Hatanpaa, Kimmo J; Raisanen, Jack M; Herndon, Emily et al. (2014) Hippocampal sclerosis in dementia, epilepsy, and ischemic injury: differential vulnerability of hippocampal subfields. J Neuropathol Exp Neurol 73:136-42
Sun, Suya; Zhang, Hua; Liu, Jie et al. (2014) Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron 82:79-93
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606
van Blitterswijk, Marka; Mullen, Bianca; Wojtas, Aleksandra et al. (2014) Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Mol Neurodegener 9:38
Liu, Jie; Zhu, Yong-Sheng; Khan, Muhammad Ayaz et al. (2014) Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment. Alzheimers Dement 10:162-70
Monson, Nancy L; Ireland, Sara J; Ligocki, Ann J et al. (2014) Elevated CNS inflammation in patients with preclinical Alzheimer's disease. J Cereb Blood Flow Metab 34:30-3
Roane, Brandy M; Johnson, Leigh; Edwards, Melissa et al. (2014) The link between sleep disturbance and depression among Mexican Americans: a Project FRONTIER study. J Clin Sleep Med 10:427-31
Edwards, Melissa; Johnson, Leigh; Mauer, Cortney et al. (2014) Regional specific groundwater arsenic levels and neuropsychological functioning: a cross-sectional study. Int J Environ Health Res 24:546-57
van Blitterswijk, Marka; Mullen, Bianca; Nicholson, Alexandra M et al. (2014) TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathol 127:397-406
Bit-Ivan, Esther N; Lee, Kyung-Hwa; Gitelman, Darren et al. (2014) Adult polyglucosan body disease with GBE1 haploinsufficiency and concomitant frontotemporal lobar degeneration. Neuropathol Appl Neurobiol 40:778-82

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