The University of Michigan requests funding for Years 16 - 20 of our Nathan Shock Center. UM receives more NIA funding than any other institution, and 48 grants in the biology of aging provide $10.4m/year in annual funding. Our Center's 2006 move to the new BSR building provided 21,000 square feet for Biogerontology, and allowed recruitment of four new tenure track researchers studying aging in mice, flies, and worms. The NSC Administrative Core will be led by Richard A. Miller, who will also serve as the Center Director. This core will facilitate communication among biogerontologists at UM and at other institutions, and take responsibility for advisory committees, interaction with UM and NIH officials, and supervision of an animal resource sharing website. The Research Development Core, headed by Susan Brooks, will administer a pilot grants program, organize an annual conference on a topic in aging research, and provide mentoring and financial support for a select group of junior faculty scientists. The Aging Rodent Core, led by Evan Keller, will support production of new transgenic and knockout mice, pay per diem costs to allow scientists to raise mice to old ages, and contribute to the costs of histopathologic analyses in the context of lifespan studies. The Drosophila Aging Core, directed by Scott Pletcher, will provide specialized equipment and validated protocols to support studies of aging, in flies, by experienced Drosophila geneticists new to aging, and by gerontologists who are just starting to incorporate Drosophila into their program. The Comparative Biogerontology Core, headed by Richard Miller, will create and characterize short-term primary fibroblast cells from a wide range of short-lived and long-lived rodents, primates, bats, birds, and dogs, and stimulate research at UM and elsewhere into cellular traits correlated with longevity across species. The Functional Assessment Core, directed by Greg Cartee, will provide advice and financial assistance to UM scientists who wish to make use of UM's exceptionally rich set of biomedical service core laboratories, to help Shock Center scientists, especially junior faculty members, introduce advanced methodologies into their research programs, including work on aims that might otherwise be deemed too risky or ambitious to tackle.

Public Health Relevance

The UM Nathan Shock Center will suppport a wide range of research projects on fundamental questions in the biology of aging. The outcome of these studies may offer new Insights into strategies to prevent disease and maintain excellent health at older ages.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (M1))
Program Officer
Sierra, Felipe
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Dostál, Lubomír; Kohler, William M; Penner-Hahn, James E et al. (2015) Fibroblasts from long-lived rodent species exclude cadmium. J Gerontol A Biol Sci Med Sci 70:9-Oct
Li, Weiquan; Miller, Richard A (2015) Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. J Gerontol A Biol Sci Med Sci 70:263-72
Kocak, Hande; Ballew, Bari J; Bisht, Kamlesh et al. (2014) Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. Genes Dev 28:2090-102
Park, Hwan-Woo; Park, Haeli; Semple, Ian A et al. (2014) Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers. Nat Commun 5:4834
Sadagurski, Marianna; Landeryou, Taylor; Blandino-Rosano, Manuel et al. (2014) Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis. Am J Physiol Endocrinol Metab 306:E1305-14
Park, Hwan-Woo; Park, Haeli; Ro, Seung-Hyun et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5:4233
Chen, Zheng; Morris, David L; Jiang, Lin et al. (2014) SH2B1 in ?-cells promotes insulin expression and glucose metabolism in mice. Mol Endocrinol 28:696-705
Ro, Seung-Hyun; Nam, Myeongjin; Jang, Insook et al. (2014) Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A 111:7849-54
Waterson, Michael J; Chung, Brian Y; Harvanek, Zachary M et al. (2014) Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proc Natl Acad Sci U S A 111:8137-42
Ro, Jennifer; Harvanek, Zachary M; Pletcher, Scott D (2014) FLIC: high-throughput, continuous analysis of feeding behaviors in Drosophila. PLoS One 9:e101107

Showing the most recent 10 out of 133 publications