The University of Michigan requests funding for Years 16 - 20 of our Nathan Shock Center. UM receives more NIA funding than any other institution, and 48 grants in the biology of aging provide $10.4m/year in annual funding. Our Center's 2006 move to the new BSR building provided 21,000 square feet for Biogerontology, and allowed recruitment of four new tenure track researchers studying aging in mice, flies, and worms. The NSC Administrative Core will be led by Richard A. Miller, who will also serve as the Center Director. This core will facilitate communication among biogerontologists at UM and at other institutions, and take responsibility for advisory committees, interaction with UM and NIH officials, and supervision of an animal resource sharing website. The Research Development Core, headed by Susan Brooks, will administer a pilot grants program, organize an annual conference on a topic in aging research, and provide mentoring and financial support for a select group of junior faculty scientists. The Aging Rodent Core, led by Evan Keller, will support production of new transgenic and knockout mice, pay per diem costs to allow scientists to raise mice to old ages, and contribute to the costs of histopathologic analyses in the context of lifespan studies. The Drosophila Aging Core, directed by Scott Pletcher, will provide specialized equipment and validated protocols to support studies of aging, in flies, by experienced Drosophila geneticists new to aging, and by gerontologists who are just starting to incorporate Drosophila into their program. The Comparative Biogerontology Core, headed by Richard Miller, will create and characterize short-term primary fibroblast cells from a wide range of short-lived and long-lived rodents, primates, bats, birds, and dogs, and stimulate research at UM and elsewhere into cellular traits correlated with longevity across species. The Functional Assessment Core, directed by Greg Cartee, will provide advice and financial assistance to UM scientists who wish to make use of UM's exceptionally rich set of biomedical service core laboratories, to help Shock Center scientists, especially junior faculty members, introduce advanced methodologies into their research programs, including work on aims that might otherwise be deemed too risky or ambitious to tackle.

Public Health Relevance

The UM Nathan Shock Center will suppport a wide range of research projects on fundamental questions in the biology of aging. The outcome of these studies may offer new Insights into strategies to prevent disease and maintain excellent health at older ages.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013283-20
Application #
8701166
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Sierra, Felipe
Project Start
1997-07-15
Project End
2015-06-30
Budget Start
2014-08-15
Budget End
2015-06-30
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Sharma, Naveen; Arias, Edward B; Cartee, Gregory D (2016) Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle. Appl Physiol Nutr Metab 41:1208-1211
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Oh, Eunjin; Miller, Richard A; Thurmond, Debbie C (2015) Syntaxin 4 Overexpression Ameliorates Effects of Aging and High-Fat Diet on Glucose Control and Extends Lifespan. Cell Metab 22:499-507
Kim, Myungjin; Semple, Ian; Kim, Boyoung et al. (2015) Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. Autophagy 11:1358-72
Waterson, Michael J; Chan, Tammy P; Pletcher, Scott D (2015) Adaptive Physiological Response to Perceived Scarcity as a Mechanism of Sensory Modulation of Life Span. J Gerontol A Biol Sci Med Sci 70:1088-91

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