The Pathology Core will play a key role in the San Antonio Nathan Shock Aging Center because pathology increases exponentially with advancing age and is largely responsible for age-related morbidity and mortality. Knowledge of the pathological lesions associated with interventions that the Center will use to study aging is essential to interpreting the impact of these interventions on the aging process(es). This knowledge will also provide insight into the underlying mechanism(s) of the interventions. The pathological assessment of old animals is important when determining whether the changes observed as animals age are associated with or independent of underlying pathological conditions. It is, therefore, essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core described herein will build on the extensive experience of researchers at San Antonio and the expertise of the Core Leader in rodent pathology analyses.
The Specific Aims of the Pathology Core are as follows: 1 2. To conduct comprehensive end-of-life and cross-sectional pathological analyses of established and new rodent models, and other species used in aging research that die spontaneously in the aging colonies maintained in the Aging Animal and Longevity Assessment Core. To conduct quantitative morphometric analyses of the tissues/organs of transgenic rodents and their control littermates examined by the 3D and 2D image analyses. To develop a comprehensive database of histopathologic findings as a resource for trend analyses by bioinformatics personnel, to provide basic pathological information for new investigations, and to develop a tissue archive by collecting and storing tissue samples to provide a resource for the analysis of samples by special request and for new morphological research. To assist faculty and students who are interested in conducting basic biological animal research in aging with the pathological analyses needed for grant applications and manuscripts preparation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013319-19
Application #
8572593
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$122,571
Indirect Cost
$40,584
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Branch, Sarah Y; Sharma, Ramaswamy; Beckstead, Michael J (2014) Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons. J Neurosci 34:9310-8
Ratnam, Sarayu; Engler, Peter; Bozek, Grazyna et al. (2014) Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis. Development 141:2024-34
Zhang, Yiqiang; Bokov, Alex; Gelfond, John et al. (2014) Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci 69:119-30
Edrey, Yael H; Salmon, Adam B (2014) Revisiting an age-old question regarding oxidative stress. Free Radic Biol Med 71:368-78
Boiko, Nina; Kucher, Volodymyr; Wang, Bin et al. (2014) Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. PLoS One 9:e91326
Liu, Yuhong; Diaz, Vivian; Fernandez, Elizabeth et al. (2014) Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging (Albany NY) 6:742-54
Elbourkadi, Najoua; Austad, Steven N; Miller, Richard A (2014) Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK. Aging Cell 13:283-91
Hasty, Paul; Livi, Carolina B; Dodds, Sherry G et al. (2014) eRapa restores a normal life span in a FAP mouse model. Cancer Prev Res (Phila) 7:169-78
Fok, Wilson C; Bokov, Alex; Gelfond, Jonathan et al. (2014) Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. Aging Cell 13:311-9
Strong, Randy; Miller, Richard A; Astle, Clinton M et al. (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 68:6-16

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