The Research Development Core provides support for career development of junior faculty and more senior investigators who wish to apply their expertise in related research areas to basic aging research. To accomplish these aims, the Core administers a Pilot Project Program and an Emerging Technologies Program. The other main function served by the Research Development Core is to coordinate mentoring activities for junior/new investigators. For several mentoring activities, the Core acts to coordinate activities between the Administrative/Program Enrichment Core and the research resources cores. Pilot Project Program: The Pilot Project Program provides the main vehicle by which faculty are selected for support by the Research Development Core. Following review by 2 external reviewers and the San Antonio Nathan Shock Center Executive Committee, Pilot Project grants of up $50,000 are awarded in three categories: (1) Projects submitted by junior faculty who are emerging as independent investigators;(2) Projects submitted by senior faculty members who have not previously been involved in aging research;(3) Special projects examining novel ideas of high programmatic relevance to aging research at UTHSCSA. Emerging Technologies Program: The Emerging Technologies Program is a new venture of the Core intended to facilitate rapid and optimal use of emerging technologies available at UTHSCSA to researchers working in aging. There are several outstanding University Cores available to Center faculty at the institution;particularly, the Core Optical Imaging Facility serves to provide state-of-the-art facilities for imaging as applied to aging research. We will offer personnel support, funds for research supplies, and service fees in 4-6 awards for a total of $40,000 per year under this program. Mentoring Activities: 25 senior faculty members have agreed to participate in mentoring activities. The primary activity will be to assist successful applicants in the Pilot Project Program to use their findings resulting from their awards to become established members of the biological gerontology community and to obtain major extramural awards. Additionally, a new mentoring initiative will expedite interactions between basic scientists and clinicians. Selected junior/new faculty whose research has translational aspects will be matched with appropriate clinicians under the guidance of two senior clinical faculty members.

Public Health Relevance

The Research Development Core is a required component of the Nathan Shock Center. By providing support to Center faculty in the form of pilot grants, and salary/supplies to support emerging technologies in faculty research in aging, the Core acts to expand the scope of research in the basic biology of aging at UTHSCSA and to maintain the preeminence of this institution in the field of aging research. By mentoring new investigators, the Core helps to create the next generation of researchers in biological gerontology.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013319-20
Application #
8701169
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
20
Fiscal Year
2014
Total Cost
$210,494
Indirect Cost
$69,696
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Sataranatarajan, Kavithalakshmi; Ikeno, Yuji; Bokov, Alex et al. (2016) Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes. J Gerontol A Biol Sci Med Sci 71:850-7
Strong, Randy; Miller, Richard A; Antebi, Adam et al. (2016) Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell 15:872-84
Melton, David W; Roberts, Alexander C; Wang, Hanzhou et al. (2016) Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration. J Leukoc Biol 100:1011-1025
Pomilio, Carlos; Pavia, Patricio; Gorojod, Roxana Mayra et al. (2016) Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization. Hippocampus 26:194-210
Treuting, P M; Snyder, J M; Ikeno, Y et al. (2016) The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents. Vet Pathol 53:244-9
Richardson, Arlan; Austad, Steven N; Ikeno, Yuji et al. (2016) Significant life extension by ten percent dietary restriction. Ann N Y Acad Sci 1363:11-7
Richardson, Arlan; Fischer, Kathleen E; Speakman, John R et al. (2016) Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci 71:427-30
Salmon, Adam B; Kim, Geumsoo; Liu, Chengyu et al. (2016) Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice. Redox Biol 10:251-256
Wu, Junjie; Sun, Yun; Block, Travis J et al. (2016) Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics. Stem Cell Res Ther 7:176
Fischer, Kathleen E; Hoffman, Jessica M; Sloane, Lauren B et al. (2016) A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated. Aging (Albany NY) 8:2370-2391

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