The purpose of the Aging Animal and Longevity Assessment Core is to provide Center investigators and researchers in aging outside the University with a broad spectrum of uniformly maintained, specific-pathogen free rodent models for the study of aging, according to their needs. The Core will continue to play a central role in the Nathan Shock Aging Center. All animals in the Core will be supported by NIA or other aging grants. The Core will breed, maintain and monitor aging rodent colonies, determine their longevity and age-related changes in weight, body composition and food intake, and distribute these animals to Center members and others for basic research on aging. In addition, the Core will maintain for pilot studies small populations of two murine models that Center investigators have recently found to have exceptional potential for understanding fundamental mechanisms of aging: 1) rapamycin-treated genetically heterogeneous mice and 2) two groups of recombinant inbred mouse strains at the extremes of the distribution of strain responses to calorie restriction (CR) ? one group of strains that shows characteristic life extension in response to CR and the other group of strains that responds with life shortening. These and other advances enabled by this Core underscore its importance as a generator of biogerontologic discovery.
The Specific Aims of the Core are as follows: 1 To breed and maintain new and established rodent models for study of the mechanism of aging and/or age-related disease processes. To conduct lifespan studies of genetically, nutritionally, or pharmacologically manipulated models according to the requirements of investigators funded by the NIA and other granting sources. To provide animal models of exceptional biogerontological interest for baseline pilot studies. To provide diets containing rapamycin and other drugs to the biogerontological community at large. To educate and advise faculty, fellows, and students interested in aging on the special requirements of animal husbandry in aging research.

Public Health Relevance

The Aging Animal and Longevity Assessment Core has played a key role in many of the important discoveries supported by Shock Center Cores, including the finding of drugs that extend mouse lifespan, tests of the oxidative stress theory of aging, and the discovery that the life-extending effect of calorie restriction may not be universal. By providing staff trained in specialized care of aging animals, reliable and reproducible determinations of longevity, and some of the longest lived mice at any institution,, this Core will continue to serve as an important resource to aging investigators both locally and nationally.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013319-20
Application #
8701171
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
20
Fiscal Year
2014
Total Cost
$162,177
Indirect Cost
$53,697
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703
Mao, Kai; Quipildor, Gabriela Farias; Tabrizian, Tahmineh et al. (2018) Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun 9:2394
Lee, Hak Joo; Feliers, Denis; Barnes, Jeffrey L et al. (2018) Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience 40:163-176
Kang, Donghoon; Kirienko, Daniel R; Webster, Phillip et al. (2018) Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. Virulence 9:804-817
Hook, Michael; Roy, Suheeta; Williams, Evan G et al. (2018) Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochim Biophys Acta Mol Basis Dis 1864:2718-2732
Van Skike, Candice E; Galvan, Veronica (2018) A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology 64:205-211
Kraig, Ellen; Linehan, Leslie A; Liang, Hanyu et al. (2018) A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol 105:53-69
Ungvari, Zoltan; Tarantini, Stefano; Donato, Anthony J et al. (2018) Mechanisms of Vascular Aging. Circ Res 123:849-867
Weiss, Roxanne; Fernandez, Elizabeth; Liu, Yuhong et al. (2018) Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice. Aging (Albany NY) :
Qin, Kunhua; Zhang, Ning; Zhang, Zhao et al. (2018) SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice. Diabetologia 61:906-918

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