The primary mission of the Boston University Alzheimer's Disease Center (BU ADC) Data Management and Statistics Core (DMSC) is to provide leadership and expertise in all phases of data management and statistical analyses, from research project development to publication of results. This collaborative assistance encompasses analytic plan development, database design, implementation of quality control procedures, technical support, creation of analytic datasets, statistical analyses, and manuscript preparation. DMSC faculty and staff maintain ongoing communication and interactions in collaborative relationship with members of all other BU ADC Cores and projects as well as the National Alzheimer's Coordinating Center (NACC). To continue accomplishing these goals into the next funding cycle, the DSMC will continue to leverage DMSC resources, including state-of-the-art hardware, software and expertise, to enable the appropriate management and analysis of data resulting from BU ADC.
The specific aims of the DMSC are:
Specific Aim 1. Provide data system expertise, assistance, and an enhanced infrastructure, including hardware, software, networks, and procedures, to ensure data security and integrity across the BU ADC.
Specific Aim 2. Provide expertise and assistance in developing and updating existing data systems for data collection, participant and data tracking, data management, and quality control procedures for BU ADC activities, including the Uniform Data Set (UDS), neuropathology, NACC, and requests from local Investigators. Maintain and expand training of all BU ADC faculty and staff in use of data systems through written materials and in-person and web-based training sessions.
Specific Aim 3. Continue to support and manage BU ADC data and resource sharing with NACC and local BU investigators. This support includes the transmittal of raw UDS and Neuropathology data to NACC as well as creation of analytic datasets, including calculated variables, for specific, approved analyses;and support and management of all resource requests, including data, participants, tissue, and animals.
Specific Aim 4. Provide high-level data management and biostatistical expertise, support and consulting to BU ADC investigators and new BU ADC-affiliated proposals and pilot grant projects, including study design, implementation and interpretation of data analyses, preparation of funding applications, and manuscript development.

Public Health Relevance

Providing the BU ADC with state of the art data management systems, and procedures and training in the use of those sytsems and procedures will ensure that only the highest quality data will be used in all BU ADC research. Advising on appropriate study design methodology and analytic techniques and providing analytic support and statistical programming will ultimate ensure the scientific integrity of research findings.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30AG013846-19
Application #
8690708
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Boston University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02118
Westwood, Andrew J; Beiser, Alexa; Decarli, Charles et al. (2014) Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology 82:1613-9
Jaywant, Abhishek; Musto, Giovanni; Neargarder, Sandy et al. (2014) The effect of Parkinson's disease subgroups on verbal and nonverbal fluency. J Clin Exp Neuropsychol 36:278-89
Weinstein, Galit; Beiser, Alexa S; Choi, Seung Hoan et al. (2014) Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol 71:55-61
McKee, Ann C; Daneshvar, Daniel H; Alvarez, Victor E et al. (2014) The neuropathology of sport. Acta Neuropathol 127:29-51
Waring, Jill D; Seiger, Ashley N; Solomon, Paul R et al. (2014) Memory for the 2008 presidential election in healthy ageing and mild cognitive impairment. Cogn Emot 28:1407-21
Mandelblatt, Jeanne S; Stern, Robert A; Luta, Gheorghe et al. (2014) Cognitive impairment in older patients with breast cancer before systemic therapy: is there an interaction between cancer and comorbidity? J Clin Oncol 32:1909-18
Korkmaz, Orhan Tansel; Aytan, Nurgul; Carreras, Isabel et al. (2014) 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. Neurosci Lett 566:286-91
Nalls, Mike A; Pankratz, Nathan; Lill, Christina M et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46:989-93
Logue, Mark W; Schu, Matthew; Vardarajan, Badri N et al. (2014) Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways. Neurobiol Aging 35:1510.e7-18
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606

Showing the most recent 10 out of 347 publications