Since 1996, the Boston University Alzheimer's Disease Center (BU ADC) Neuropathology Core has conducted and facilitated cutting-edge research on the neuropathology of Alzheimer's disease (AD) and is recognized internationally for outstanding contributions to neuropathological diagnosis and clinicopathological analysis. Under the consistent leadership of Dr. Ann McKee, the Core continues to provide advances in our understanding of preclinical AD, the contribution of microvascular injury to cognitive impairment, the effects of repetitive trauma on neurodegeneration, and the result of protracted aging on the brain. The BU ADC Neuropathology Core serves diverse brain donor cohorts, which include the internationally-renowned Framingham Heart Study (FHS), the Centenarian Study (CEN), and, most recently, the Center for the Study of Traumatic Encephalopathy (CSTE). Innovations include the collection of supplemental tissue, including eyes and spinal cord tissue, in addition to brain and cerebrospinal fluid. Our Neuropathology Core has pioneered standardized criteria for rating microvascular pathology to assess the contribution of gross and microvascular pathology to cognitive impairment. We were the first group to recognize the eariy neurofibrillary degeneration of the posterior visual association cortex in preclinical AD. Furthermore, the BU ADC Neuropathology Core infrastructure was leveraged to create the BU CSTE, which has provided groundbreaking research on the long-term neurodegenerative consequences of repetitive mild traumatic brain injury. We have defined the essential clinical and neuropathological features of Chronic Traumatic Encephalopathy (CTE), a progressive neurodegenerative disorder characterized by the accumulation of hyperphosphorylated tau and TDP-43 proteins. In the next cycle, we will assess the relationship between ischemic injury and cognitive status and validate the diagnostic criteria that distinguish CTE from other tauopathies and TDP-43 proteinopathies, including AD. Through institutional support from the Edith Nourse Rogers Memorial Veterans Hospital in Bedford, MA, the newly renovated neuropathology laboratories have doubled in size with state-of-the-art Leica equipment. Three histology technicians and a MD pathologist have been added, and we are currently recruiting an additional neuropathologist. Although there has been a dramatic expansion in the capabilities and institutional infrastructure in the past four years, none of these accomplishments could have taken place without the framework and personnel provided by the BU ADC Neuropathology Core, whose existence continues to be absolutely central to all our endeavors.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1)
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Boston University
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Westwood, Andrew J; Beiser, Alexa; Decarli, Charles et al. (2014) Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology 82:1613-9
Jaywant, Abhishek; Musto, Giovanni; Neargarder, Sandy et al. (2014) The effect of Parkinson's disease subgroups on verbal and nonverbal fluency. J Clin Exp Neuropsychol 36:278-89
Weinstein, Galit; Beiser, Alexa S; Choi, Seung Hoan et al. (2014) Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol 71:55-61
McKee, Ann C; Daneshvar, Daniel H; Alvarez, Victor E et al. (2014) The neuropathology of sport. Acta Neuropathol 127:29-51
Waring, Jill D; Seiger, Ashley N; Solomon, Paul R et al. (2014) Memory for the 2008 presidential election in healthy ageing and mild cognitive impairment. Cogn Emot 28:1407-21
Mandelblatt, Jeanne S; Stern, Robert A; Luta, Gheorghe et al. (2014) Cognitive impairment in older patients with breast cancer before systemic therapy: is there an interaction between cancer and comorbidity? J Clin Oncol 32:1909-18
Korkmaz, Orhan Tansel; Aytan, Nurgul; Carreras, Isabel et al. (2014) 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. Neurosci Lett 566:286-91
Nalls, Mike A; Pankratz, Nathan; Lill, Christina M et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46:989-93
Logue, Mark W; Schu, Matthew; Vardarajan, Badri N et al. (2014) Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways. Neurobiol Aging 35:1510.e7-18
Beecham, Gary W; Hamilton, Kara; Naj, Adam C et al. (2014) Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet 10:e1004606

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