Since 1996, the Boston University Alzheimer's Disease Center (BU ADC) Neuropathology Core has conducted and facilitated cutting-edge research on the neuropathology of Alzheimer's disease (AD) and is recognized internationally for outstanding contributions to neuropathological diagnosis and clinicopathological analysis. Under the consistent leadership of Dr. Ann McKee, the Core continues to provide advances in our understanding of preclinical AD, the contribution of microvascular injury to cognitive impairment, the effects of repetitive trauma on neurodegeneration, and the result of protracted aging on the brain. The BU ADC Neuropathology Core serves diverse brain donor cohorts, which include the internationally-renowned Framingham Heart Study (FHS), the Centenarian Study (CEN), and, most recently, the Center for the Study of Traumatic Encephalopathy (CSTE). Innovations include the collection of supplemental tissue, including eyes and spinal cord tissue, in addition to brain and cerebrospinal fluid. Our Neuropathology Core has pioneered standardized criteria for rating microvascular pathology to assess the contribution of gross and microvascular pathology to cognitive impairment. We were the first group to recognize the eariy neurofibrillary degeneration of the posterior visual association cortex in preclinical AD. Furthermore, the BU ADC Neuropathology Core infrastructure was leveraged to create the BU CSTE, which has provided groundbreaking research on the long-term neurodegenerative consequences of repetitive mild traumatic brain injury. We have defined the essential clinical and neuropathological features of Chronic Traumatic Encephalopathy (CTE), a progressive neurodegenerative disorder characterized by the accumulation of hyperphosphorylated tau and TDP-43 proteins. In the next cycle, we will assess the relationship between ischemic injury and cognitive status and validate the diagnostic criteria that distinguish CTE from other tauopathies and TDP-43 proteinopathies, including AD. Through institutional support from the Edith Nourse Rogers Memorial Veterans Hospital in Bedford, MA, the newly renovated neuropathology laboratories have doubled in size with state-of-the-art Leica equipment. Three histology technicians and a MD pathologist have been added, and we are currently recruiting an additional neuropathologist. Although there has been a dramatic expansion in the capabilities and institutional infrastructure in the past four years, none of these accomplishments could have taken place without the framework and personnel provided by the BU ADC Neuropathology Core, whose existence continues to be absolutely central to all our endeavors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013846-19
Application #
8690709
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Boston University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02118
Burke, Shanna L; Hu, Tianyan; Fava, Nicole M et al. (2018) Sex differences in the development of mild cognitive impairment and probable Alzheimer's disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging :1-25
Guan, Yue; Roter, Debra L; Wolff, Jennifer L et al. (2018) The impact of genetic counselors' use of facilitative strategies on cognitive and emotional processing of genetic risk disclosure for Alzheimer's disease. Patient Educ Couns 101:817-823
Li, Jinlei; Ogrodnik, Matthew; Devine, Sherral et al. (2018) Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study. Alzheimers Dement 14:35-42
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
Wang, Tingyan; Qiu, Robin G; Yu, Ming (2018) Predictive Modeling of the Progression of Alzheimer's Disease with Recurrent Neural Networks. Sci Rep 8:9161
Agogo, George O; Ramsey, Christine M; Gnjidic, Danijela et al. (2018) Longitudinal associations between different dementia diagnoses and medication use jointly accounting for dropout. Int Psychogeriatr 30:1477-1487
Alosco, Michael L; Sugarman, Michael A; Besser, Lilah M et al. (2018) A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis 63:1347-1360
Cherry, Jonathan D; Mez, Jesse; Crary, John F et al. (2018) Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun 6:115
Brent, Robert J (2018) Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia. Appl Econ 50:6327-6340
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872

Showing the most recent 10 out of 791 publications