In response to the RFA, the Neuropathology Core of the Northwestern ADC will continue to provide state of- the-art diagnostic services, collect well-prepared biospecimens, and distribute samples, according to the best practice guidelines set forth by the NIA Biospecimen Task Force, for cutting edge research, locally, in cooperation with other Centers, and with researchers outside of Centers, in order to address the Core's Specific Aims: 1) Provide state-of-the-art postmortem diagnosis on Clinical Core subjects with dementia, MCI, and NCI, and make the results available to the family, relevant clinicians, qualified researchers, and NACC. 2) Collect, store, and distribute brain, CSF, blood products, and DNA, to suit the requirements of qualified research projects, both within Northwestern University and for national and international collaborations. 3) Support the specialized research interests within Northwestern University on non-AD dementias such as frontotemporal dementia (FTD), motor neuron disease (MND or ALS) with cognitive impairment, and primary progressive aphasia (PPA). 4) Facilitate multidisciplinary research, where molecular insights or clinical patterns can be correlated with the systems-level distribution of neuropathologic markers, via the """"""""enabling"""""""" infrastructure of the Laboratory for Cognitive and Molecular Morphometry. The Neuropathology Core will work with the other Northwestern ADC Cores to better define normal aging and the transition to MCI and eary dementia via the Northwestern ADC """"""""Super-Aging Project."""""""" The Neuropathology Core will continue to participate in large-scale collaborative national and international research efforts such as ADGWAS and TDP-GWAS, and commits to readily provide well-characterized biospecimens to such cooperative efforts. The Neuropathology Core will also provide a rich training environment for for fellows and junior faculty to develop skills and experience in interdisciplinary research on AD and related dementia.

Public Health Relevance

The Northwestern ADC is focused on very early changes of AD-type dementia and specialized dementia sub-types such as PPA and FTD, which have language and behavior abnormalities. Careful clinicopathologic correlation and molecular and genetic studies on clinically well-characterized patients and controls will lead to methods of detecting very early impairment, necessary in order to delay or prevent dementia onset.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG013854-17
Application #
8379103
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
17
Fiscal Year
2012
Total Cost
$233,488
Indirect Cost
$80,381
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
White, Matthew T; Shaw, Leslie M; Xie, Sharon X et al. (2016) Evaluation of Cerebrospinal Fluid Assay Variability in Alzheimer's Disease. J Alzheimers Dis 51:463-70
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43
Green, Colin; Zhang, Shenqiu (2016) Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model. Alzheimers Dement 12:776-85
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-50
Martersteck, Adam; Murphy, Christopher; Rademaker, Alfred et al. (2016) Is in vivo amyloid distribution asymmetric in primary progressive aphasia? Ann Neurol 79:496-501
Filshtein, Teresa; Beckett, Laurel A; Godwin, Haley et al. (2016) Incident Antipsychotic Use in a Diverse Population with Dementia. J Am Geriatr Soc 64:e44-6
Mattos, Meghan K; Snitz, Beth E; Lingler, Jennifer H et al. (2016) Older Rural- and Urban-Dwelling Appalachian Adults With Mild Cognitive Impairment. J Rural Health :
Asmus, Stephen E; Raghanti, Mary Ann; Beyerle, Eric R et al. (2016) Tyrosine hydroxylase-producing neurons in the human cerebral cortex do not colocalize with calcium-binding proteins or the serotonin 3A receptor. J Chem Neuroanat 78:1-9
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-21
LoBue, Christian; Denney, David; Hynan, Linda S et al. (2016) Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. J Alzheimers Dis 51:727-36

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