The Data Management and Statistics Core (Core C) serves multiple purposes related to data acquisition, management, standardization and biostatistical analysis. It provides a centralized repository for major species of data gathered by the clinical, educational and neuropathology cores, a source of multidimensional information for all qualified investigators conducting research projects approved by the Northwestem ADC Executive Committee, and a conduit for sharing data with NACC. It provides quality control and harmonization with standardized data sets at the point of entry and biostafisfics support at the stage of study design and data retrieval.
The first aim of Core C is to maintain an integrated database for all information collected by the Northwestern ADC including demographic, clinical, imaging, biomaterial, and neuropathological data.
The second aim i s to provide biostatistical support to Northwestern ADC investigators at all stages of research including study design, data collection and analyses, and the development of new hypotheses based on existing data. The third goal of Core C is to facilitate the use of data by approved Northwestern investigators and to encourage data sharing among investigators with the goal of developing novel collaborations.
The fourth aim i s to ensure the confidentiality and security of all data by maintaining a state of the art computer system with appropriate data protection measures and also guard against loss of data by ensuring adequate backup systems are in place. Core C also takes an active role in the design of data collection instruments and in the methods of data collection in order to maintain compliance with HIPAA and other state and federal medical records regulations. The senior biostatistician is a member of the Northwestern DC Executive Committee and all research proposals reviewed by the Executive Committee have therefore received biostatistical vetting.
The final aim of Core C is to ensure successful extramural data sharing by implementation of the UDS, timely submission of the data to NACC, relay of relevant genetic and tissue data to NCRAD, electronic data transmission to ADNI, and clinical trials data submission to ADCS.

Public Health Relevance

It is essential to a strong ADC to have not only a viable clinical cohort and accessible biological materials but to also have a means of making the data available to qualified researchers within and outside of the institution and to have bisotatistics support for planning and interpreting investigations. Core C serves the pivotal role of promoting intra-Center integration as well as fostering inter-Center collaborations.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30AG013854-19
Application #
8688116
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hohman, Timothy J; Cooke-Bailey, Jessica N; Reitz, Christiane et al. (2016) Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement 12:233-43
White, Matthew T; Shaw, Leslie M; Xie, Sharon X et al. (2016) Evaluation of Cerebrospinal Fluid Assay Variability in Alzheimer's Disease. J Alzheimers Dis 51:463-70
Hohman, Timothy J; Bush, William S; Jiang, Lan et al. (2016) Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging 38:141-50
Green, Colin; Zhang, Shenqiu (2016) Predicting the progression of Alzheimer's disease dementia: A multidomain health policy model. Alzheimers Dement 12:776-85
Filshtein, Teresa; Beckett, Laurel A; Godwin, Haley et al. (2016) Incident Antipsychotic Use in a Diverse Population with Dementia. J Am Geriatr Soc 64:e44-6
Martersteck, Adam; Murphy, Christopher; Rademaker, Alfred et al. (2016) Is in vivo amyloid distribution asymmetric in primary progressive aphasia? Ann Neurol 79:496-501
Mattos, Meghan K; Snitz, Beth E; Lingler, Jennifer H et al. (2016) Older Rural- and Urban-Dwelling Appalachian Adults With Mild Cognitive Impairment. J Rural Health :
Asmus, Stephen E; Raghanti, Mary Ann; Beyerle, Eric R et al. (2016) Tyrosine hydroxylase-producing neurons in the human cerebral cortex do not colocalize with calcium-binding proteins or the serotonin 3A receptor. J Chem Neuroanat 78:1-9
Mez, Jesse; Mukherjee, Shubhabrata; Thornton, Timothy et al. (2016) The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable. Neurobiol Aging 41:115-21
LoBue, Christian; Denney, David; Hynan, Linda S et al. (2016) Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis. J Alzheimers Dis 51:727-36

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