The Analysis Core (AnC) aims are responsive to priority areas of the NIA Health Disparities Strategic Plan (2009-2013)[1] for reducing racial/ethnic health disparities in our aging population: a) explore aging as a web of genetic, biochemical, physiological, economic, social, and psychological factors, b) find effective interventions to ensure better health for older adults, c) provide resources to promote high-quality research to reduce health disparities, and d) train a diverse workforce of investigators to conduct aging and health disparities research. Understanding determinants of disparities requires multi-level, ecological models and corresponding, psychometrically sound measures that describe policy, environmental, social, family, and individual-level determinants among minority and lower-socioeconomic status (SES) older adults. Conducting effective research in aging and health disparities requires skills in specialized methods including those related to research design, analytic methods, measurement, statistical modeling of secondary data, and adapting evidence-based interventions (EBI) for minority communities. Preventing or ameliorating effects of chronic disease is key to reducing disparities;although EBI are available, there are substantial methodological challenges to translation and implementation in communities to reach minority and lower-SES older adults. By advancing conceptual frameworks and methods, and providing training and technical assistance in these specialized areas, we can increase our collective capacity to reduce health disparities. The University of California San Francisco (UCSF) Center for Aging in Diverse Communities (CADC) Analysis Core (AnC) has worked for 14 years to develop detailed conceptual frameworks, research methods, and measures to advance research with aging minority and lower-SES populations. We have disseminated our work through publications, workshops, websites, reports, executive summaries, teaching, mentoring, and technical assistance. AnC members have experience developing and testing measures, quantitative and qualitative research methods, and secondary data analysis, and in conjunction with the Community Liaison Core (CLC) implementing interventions in community-based settings to reach ethnically diverse older adults. Over the next five years, we will continue to provide training and technical assistance to our CADC scholars and UCSF faculty and fellows in the specialized methods for conducting minority aging and health disparities research and pursue innovative methods and strategies to reduce disparities.
The specific aims are: 1. Increase application of culturally sensitive and scientifically robust measures of mechanisms of health disparities in older adults by: a) developing, evaluating, adapting, and disseminating measures of key multi-level determinants of disparities;and b) developing and disseminating self-directed resources for investigators to locate, review, and select appropriate measures for their own research; 2. Promote and facilitate use of secondary datasets in health disparities and minority aging research by providing training and technical assistance to CADC scholars and others at UCSF in: a. Use of interrupted time series design/analysis to assess effects of policy changes; b. Analysis of secondary data obtained using complex sampling designs (e.g., NHIS, NHANES); c. Linking individual-level secondary datasets to area-level information (e.g., census, other area-level information) to address area-level determinants of disparities; 3. Advance and disseminate methods for translating evidence-based interventions (EBI) to prevent and ameliorate effects of chronic diseases into community-based programs to reach lower-SES and minority older adults. We will create a conceptual model of the processes, develop practical guidelines, and provide technical assistance to scholars wishing to test interventions. By developing and disseminating innovative measurements and methodological approaches (for use with primary and secondary data), we will help build the evidence base on the complex pathways to health disparities. By tackling methodological issues in conducting interventions in ethnic communities, we will increase investigator capacity to carry out such interventions, contributing to reduced health disparities.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-3 (M1))
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University of California San Francisco
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Kalkhoran, Sara; Appelle, Nicole A; Napoles, Anna M et al. (2016) Beyond the Ask and Advise: Implementation of a Computer Tablet Intervention to Enhance Provider Adherence to the 5As for Smoking Cessation. J Subst Abuse Treat 60:91-100
Nápoles, Anna María; Appelle, Nicole; Kalkhoran, Sara et al. (2016) Perceptions of clinicians and staff about the use of digital technology in primary care: qualitative interviews prior to implementation of a computer-facilitated 5As intervention. BMC Med Inform Decis Mak 16:44
Mayeda, Elizabeth Rose; Glymour, M Maria; Quesenberry, Charles P et al. (2016) Inequalities in dementia incidence between six racial and ethnic groups over 14 years. Alzheimers Dement 12:216-24
Marden, Jessica R; Mayeda, Elizabeth R; Walter, Stefan et al. (2016) Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up. Alzheimer Dis Assoc Disord :
Vivot, Alexandre; Power, Melinda C; Glymour, M Maria et al. (2016) Jump, Hop, or Skip: Modeling Practice Effects in Studies of Determinants of Cognitive Change in Older Adults. Am J Epidemiol 183:302-14
Echeverri, Margarita; Anderson, David; Nápoles, Anna María (2016) Cancer Health Literacy Test-30-Spanish (CHLT-30-DKspa), a New Spanish-Language Version of the Cancer Health Literacy Test (CHLT-30) for Spanish-Speaking Latinos. J Health Commun 21 Suppl 1:69-78
Mejia, Raul; Pérez Stable, Eliseo J; Kaplan, Celia P et al. (2016) Effectiveness of an Intervention to Teach Physicians How to Assist Patients to Quit Smoking in Argentina. Nicotine Tob Res 18:1101-9
Izano, Monika; Wei, Esther K; Tai, Caroline et al. (2016) Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study. Int J Cancer 138:1118-28
Liu, Rhianon; Chang, Alexandra; Reddy, Sanjay et al. (2016) Improving Patient-Centered Care: A Cross-Sectional Survey of Prior Use and Interest in Complementary and Integrative Health Approaches Among Hospitalized Oncology Patients. J Altern Complement Med 22:160-5
Sternberg, Rosa Maria; Nápoles, Anna Maria; Gregorich, Steven et al. (2016) Development of the Stress of Immigration Survey: A Field Test Among Mexican Immigrant Women. Fam Community Health 39:40-52

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