The USC/UCLA Center on Biodemography and Population Health (CBPH) provides support for research in and the development of the field of Biodemography to clarify how biology mediates between social and economic factors to affect physical and mental health of the population. The integration of biological, epidemiologic and medical risk information into demographic models is fundamental to understanding and projecting demographic trends and population sub group differences in health in order to inform policy. In this application, we request continued funding for the USC/UCLA CBPH in order to: 1) support the development of cutting-edge biodemographic research among CBPH affiliates through support of pilot projects and research infrastructure;2) to support development of approaches to biodemographic data collection and valdation for demographic research through the use of pilot projects and research infrastructure 3) to further develop an active biodemographic research community both within our two universities and more broadly in the field of popualtion studies;4) to implement a new External Research Support and Dissemination Core to support development and validation of new research methodologies, including genetic factors, for use in biodemographic research and population surveys more generally;5) to disseminate broadly information on biodemographic methods. The research supported by the CBPH and the developmnet of infrastructure for measurement and integration of genetic factors will continue to improve our understanding of how individual biological risk factors, combinations of biological risk factors, and interactions of risk factors affect the total length of life, the length of life with health problems, and the population prevalence of specific chronic conditions and disabilities.

Public Health Relevance

The research supported by our Center uses demographic aproaches to clarify how individual biological risk factors affect the prevalence of diseases and disabilities, and mortality in large population samples. Results of research supported by this application can be used to clarify the effects of risk factors on race/ethnic and socioeconomic differences in health within the United States, as well as differences between the United States and other countries.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG017265-14
Application #
8493951
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (M1))
Program Officer
Haaga, John G
Project Start
1999-08-15
Project End
2014-06-30
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
14
Fiscal Year
2013
Total Cost
$426,811
Indirect Cost
$79,895
Name
University of Southern California
Department
None
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Hu, Peifeng; Edenfield, Michael; Potter, Alan et al. (2015) Validation and modification of dried blood spot-based glycosylated hemoglobin assay for the longitudinal aging study in India. Am J Hum Biol 27:579-81
Vedhara, Kavita; Gill, Sana; Eldesouky, Lameese et al. (2015) Personality and gene expression: Do individual differences exist in the leukocyte transcriptome? Psychoneuroendocrinology 52:72-82
Levine, M E; Crimmins, E M (2014) Evidence of accelerated aging among African Americans and its implications for mortality. Soc Sci Med 118:27-32
Crimmins, Eileen; Kim, Jung Ki; McCreath, Heather et al. (2014) Validation of blood-based assays using dried blood spots for use in large population studies. Biodemography Soc Biol 60:38-48
Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Levine, Morgan E; Crimmins, Eileen M; Prescott, Carol A et al. (2014) A polygenic risk score associated with measures of depressive symptoms among older adults. Biodemography Soc Biol 60:199-211
Ailshire, Jennifer A; Crimmins, Eileen M (2014) Fine particulate matter air pollution and cognitive function among older US adults. Am J Epidemiol 180:359-66
Cole, Steven W (2014) Human social genomics. PLoS Genet 10:e1004601
Miller, Gregory E; Murphy, Michael L M; Cashman, Rosemary et al. (2014) Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav Immun 41:191-9
Levine, Morgan; Crimmins, Eileen (2014) Not all smokers die young: a model for hidden heterogeneity within the human population. PLoS One 9:e87403

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