The overarching aim ofthe Program Development Core (PDC) is to provide pilot funding to support innovative and ground-breaking work on questions relating to population health. As outlined in our Center overview, major thematic/substantive areas of interest include: (1) elucidation of biological mechanisms (with increased emphasis on genetic/epigenetic processes), (2) life-course perspectives on population health (e.g., understanding eariy life and other cumulative influences on health trajectories, (3) increased understanding of cognitive aging across and within populations, and (4) international comparisons (e.g., to better understand population race/ethnic and SES health disparities). Paralleling our commitment to support for innovative science is our commitment to continued support for promising junior faculty, seeking to encourage the on-going development of a cadre of talented researchers focusing on interdisciplinary questions related to demography and population health as well as efforts to encourage talented, mid- (and even later) career faculty to incorporate a more bio-demographic focus to their program of research. To achieve these aims the PDC will work with the ARC to solicit and guide pilot projects.
The pilot projects ofthe CBPH continue to improve our understanding of how individual biological risk factors, combinations of biological risk factors, and interactions of risk factors affect the length of life, the length of life with health problems, and the numbers of people with specific chronic conditions and disabilities. This understanding is central to planning for the future costs and needs of an aging population.
|Crimmins, Eileen M; Zhang, Yuan; Saito, Yasuhiko (2016) Trends Over 4 Decades in Disability-Free Life Expectancy in the United States. Am J Public Health 106:1287-93|
|Wheaton, Felicia V; Crimmins, Eileen M (2016) Female disability disadvantage: a global perspective on sex differences in physical function and disability. Ageing Soc 36:1136-1156|
|Carroll, Judith E; Cole, Steven W; Seeman, Teresa E et al. (2016) Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun 51:223-9|
|Kohrt, Brandon A; Worthman, Carol M; Adhikari, Ramesh P et al. (2016) Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers. Proc Natl Acad Sci U S A 113:8156-61|
|Mitchell, Uchechi A; Ailshire, Jennifer A; Brown, Lauren L et al. (2016) Education and Psychosocial Functioning Among Older Adults: 4-Year Change in Sense of Control and Hopelessness. J Gerontol B Psychol Sci Soc Sci :|
|Min, Joohong; Ailshire, Jennifer; Crimmins, Eileen M (2016) Social engagement and depressive symptoms: do baseline depression status and type of social activities make a difference? Age Ageing 45:838-843|
|Finch, Caleb E; Crimmins, Eileen M (2016) Constant molecular aging rates vs. the exponential acceleration of mortality. Proc Natl Acad Sci U S A 113:1121-3|
|Knight, Jennifer M; Rizzo, J Douglas; Logan, Brent R et al. (2016) Low Socioeconomic Status, Adverse Gene Expression Profiles, and Clinical Outcomes in Hematopoietic Stem Cell Transplant Recipients. Clin Cancer Res 22:69-78|
|Dooley, Larissa N; Ganz, Patricia A; Cole, Steve W et al. (2016) Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer. J Affect Disord 197:43-50|
|Tiedt, Andrew D; Saito, Yasuhiko; Crimmins, Eileen M (2016) Depressive Symptoms, Transitions to Widowhood, and Informal Support From Adult Children Among Older Women and Men in Japan. Res Aging 38:619-42|
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