The USC/UCLA Center on Biodemography and Population Health (CBPH) represents a unique and highly successful collaboration between the Davis School of Gerontology of the University of Southern California (USC) and the Multi-campus Program in Geriatric Medicine and Gerontology in the Geffen School of Medicine at the University of California at Los Angeles (UCLA), each of which focuses on research and teaching on aging. Since its inception in 1999, the CBPH has leveraged the unique combination of demographic and epidemiological expertise of the CBPH directors, along with the range of interdisciplinary expertise of CBPH faculty affiliates, to become a leader in the development of the field of biodemography. The CBPH has been at the forefront of efforts to promote theory-based integration of biological measurement into population-based studies and on-going development and validation of biological measurement protocols. The CBPH has effectively and efficiently developed infrastructure and pilot projects to improve understanding and use of biodemographic indicators, increase indicators available to population studies, support more reliable and valid collection of data across a large number of national and international surveys, help introduce genetics to demographic and economic researchers, and made advances in measurement and validation in the field of genetics/genomics that allow population surveys to keep pace with the scientific advances in this area. This application proposes a set of activities designed to (i) expand and enhance theoretical development of the field of biodemography, (ii) continue efforts to attract new and promising researchers to the field, and (iii) enhance our Center's unique role in supporting development, validation, implementation and dissemination of new and better biodemographic measurement protocols.
The specific aims of the CBPH will be to: (1) support and foster biodemographic research to understand the multiple and interacting factors that affect population health (with a particular focus on expanding and deepening our understanding of the biological pathways through which experiences and exposures over the life-course impact trajectories of health and how such influences may vary across subgroups and settings)

Public Health Relevance

The research supported by our Center attempts to clarify the biological pathways through which social, economic, and psychological and experiences impact health and how such influences may vary across subgroups and settings. This knowledge will increase our ability to improve health and reduce health disparities.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
2P30AG017265-15
Application #
8743589
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Haaga, John G
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Southern California
Department
None
Type
Other Specialized Schools
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Crimmins, Eileen M; Zhang, Yuan; Saito, Yasuhiko (2016) Trends Over 4 Decades in Disability-Free Life Expectancy in the United States. Am J Public Health 106:1287-93
Wheaton, Felicia V; Crimmins, Eileen M (2016) Female disability disadvantage: a global perspective on sex differences in physical function and disability. Ageing Soc 36:1136-1156
Carroll, Judith E; Cole, Steven W; Seeman, Teresa E et al. (2016) Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans. Brain Behav Immun 51:223-9
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Min, Joohong; Ailshire, Jennifer; Crimmins, Eileen M (2016) Social engagement and depressive symptoms: do baseline depression status and type of social activities make a difference? Age Ageing 45:838-843
Finch, Caleb E; Crimmins, Eileen M (2016) Constant molecular aging rates vs. the exponential acceleration of mortality. Proc Natl Acad Sci U S A 113:1121-3
Knight, Jennifer M; Rizzo, J Douglas; Logan, Brent R et al. (2016) Low Socioeconomic Status, Adverse Gene Expression Profiles, and Clinical Outcomes in Hematopoietic Stem Cell Transplant Recipients. Clin Cancer Res 22:69-78
Dooley, Larissa N; Ganz, Patricia A; Cole, Steve W et al. (2016) Val66Met BDNF polymorphism as a vulnerability factor for inflammation-associated depressive symptoms in women with breast cancer. J Affect Disord 197:43-50
Tiedt, Andrew D; Saito, Yasuhiko; Crimmins, Eileen M (2016) Depressive Symptoms, Transitions to Widowhood, and Informal Support From Adult Children Among Older Women and Men in Japan. Res Aging 38:619-42

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