The overarching aim of the Program Development Core (PDC) is to provide pilot funding to support the development of innovative and ground-breaking research that will lead to a fuller understanding of the processes affecting population health at older ages and how these processes are faster or slower given biological, social, behavioral, psychological, economic, environmental, and health care conditions. Prior Center pilot projects have significantly increased our understanding of the roles of life circumstances, behaviors, stressors, biological factors, genetics in affecting health outcomes. These projects have also been highly successful in providing a basis for subsequent funded research and significant publications. In keeping with the overarching aim of the USC/UCLA Center on Biodemography and Population Health (CBPH), we devote a subset of our pilot projects to the development of innovations in biological and health measurement and data that provide increased resources for the entire research community. Our proposed pilots for the first year reflect the areas of CBPH focus: genetic/epigenetic processes;biological risk factors;international comparisons and the role of neighborhood or environmental characteristics. The PDC has also been an important mechanism for integrating and developing biodemographic researchers at our Universities including emerging scholars, new faculty, and faculty transitioning into biodemography. We have also supported pilot work from other universities that is critical to the further development of the field. The PDC is strongly integrated with the activities of the Administrative Research Core (ARC) and our Research Resources and Dissemination Core (RRDC). Some pilots produce work integrated into our national meetings organized by the ARC and some pilots either begin or transition to validation projects in the RRDC.
The research supported by our Center attempts to clarify the biological pathways through which social, economic, and psychological and experiences impact health and how such influences may vary across subgroups and settings. This knowledge will increase our ability to improve health and reduce health disparities.
|Hu, Peifeng; Edenfield, Michael; Potter, Alan et al. (2015) Validation and modification of dried blood spot-based glycosylated hemoglobin assay for the longitudinal aging study in India. Am J Hum Biol 27:579-81|
|Vedhara, Kavita; Gill, Sana; Eldesouky, Lameese et al. (2015) Personality and gene expression: Do individual differences exist in the leukocyte transcriptome? Psychoneuroendocrinology 52:72-82|
|Levine, M E; Crimmins, E M (2014) Evidence of accelerated aging among African Americans and its implications for mortality. Soc Sci Med 118:27-32|
|Crimmins, Eileen; Kim, Jung Ki; McCreath, Heather et al. (2014) Validation of blood-based assays using dried blood spots for use in large population studies. Biodemography Soc Biol 60:38-48|
|Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8|
|Levine, Morgan E; Crimmins, Eileen M; Prescott, Carol A et al. (2014) A polygenic risk score associated with measures of depressive symptoms among older adults. Biodemography Soc Biol 60:199-211|
|Ailshire, Jennifer A; Crimmins, Eileen M (2014) Fine particulate matter air pollution and cognitive function among older US adults. Am J Epidemiol 180:359-66|
|Cole, Steven W (2014) Human social genomics. PLoS Genet 10:e1004601|
|Miller, Gregory E; Murphy, Michael L M; Cashman, Rosemary et al. (2014) Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav Immun 41:191-9|
|Levine, Morgan; Crimmins, Eileen (2014) Not all smokers die young: a model for hidden heterogeneity within the human population. PLoS One 9:e87403|
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