The Clinical Research Core (CRC - Resource Core 1) of the Wake Forest University Older Americans Independence Center (WFU OAIC) provides the critical infrastructure and investigator resources essential to the successful conduct of clinical research focusing on physical function and disability in older adults. The CRC is well-integrated with the other OAIC Resource Cores (Biolmaging, Integrative Biology and Biostatistics Cores). With them, the CRC will support externally funded studies, OAlC-funded Pilot and Research Development Projects, and other externally-funded projects related to the WFU OAIC research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. A high priority for the CRC will be to support clinical trials translating basic research discoveries into human population studies;clinical research targeting sarcopenia and adiposity-related decline in physical function and disability in older adults;and trials of novel interventions related to these risk factors. The CRC will also assist the Leadership and Administrative Core (LAC), the Pilot and Exploratory Studies Core (PESC), and the Research Career Development Core (RCDC) in identifying promising new investigators and programs positioned to help to address the mechanisms and prevention of physical disability. The CRC will provide 'turn-key'resources critical for successful clinical research studies, including: 1) expertise related to experimental study design and conduct, including selection of appropriate outcome measures;2) highly efficient and effective participant recruitment 3) a standardized physical function assessment battery;4) procurement (with the Integrative Biology Core) of muscle and adipose tissue and blood samples;5) maintenance (in concert with the Biostatistics Core) of a uniform outcomes database;6) assisting junior investigators with IRB and other regulatory filings (in concert with the PESC and RCDC). In the present cycle, provision of these key resources has been integral to our timely completion of clinical studies, publication of results, competition for new independently-funded grant awards, and development of new investigators

Public Health Relevance

The Wake Forest OAIC Clinical Research Core provides research support (assessment tools, staff, space, recruitment support, etc.) for scientists interested in developing new understanding about the causes and prevention of older adults'loss of ability to live independently in their communities.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021332-11
Application #
8673566
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
Project End
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
11
Fiscal Year
2013
Total Cost
$120,989
Indirect Cost
$30,968
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
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Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2016) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc :
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Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816
Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519
Messi, María Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80

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