The goal of the WFU OAIC Biostatistics and Research Information Systems Core (BIC) is to build upon our strong successes in biostatistical collaboration and to develop a broader class of statistics/informatics tools that are tailored to research in aging. The proposed Core is comprised of a team of highly qualified investigators/staff with expertise in the design and management of observational, pilot and interventional studies, centralized and decentralized data management, forms design and data processing, image archival, psychometrics, statistical analysis of data from multiple study designs, GWAS analyses, and development of novel statistical methods. These individuals are committed to the WFU OAlC's global aims to: (1) discover;(2) evaluate;and (3) translate interventions to treat and prevent disability based on integrating novel pathways of functional decline;and (4) train the next generation of leaders in aging research.
The Specific Aims of the BIC are: 1. To participate as co-investigators for WFU OAIC projects (4 pilot studies (PES), 1 developmental projects (DP) and 8 externally funded projects (EPs)) related to OAlC's global aims. As co investigators, BIC members will be actively involved in study design and conduct (including recruitment monitoring, randomization, and safety monitoring);sample size determination;data management;and statistical analysis, interpretation and presentation/publication of results. 2. To play an integral role in training of OAlC-supported fellows and junior members of the BIC on the design, planning, conduct, and analysis of aging-related research projects. The BIC will also extend its strong record of discovery and evaluation with Specific Aims 3-4, which are to: 3. Develop additional innovative biostatistical applications/methods for analytical issues specifically associated with aging research. 4. Develop innovative research information collection systems to assist in carrying out studies in older participants and translate these tools into community- and clinic-based settings, in support of Aim 3 of the WFU OAIC overall goals.

Public Health Relevance

By providing critical infrastructure needed for study design, data collection, analysis and interpretation, the Biostatistics and Research Information Systems Core will play a pivotal role in scientific investigations to advance our knowledge of the aging process. Core members will develop new data collection and analysis tools and will participate in translation of these tools into clinic and community settings.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Wake Forest University Health Sciences
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Normandin, Eve; Chmelo, Elizabeth; Lyles, Mary F et al. (2017) Effect of Resistance Training and Caloric Restriction on the Metabolic Syndrome. Med Sci Sports Exerc 49:413-419
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2017) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc 65:137-145
Tyrrell, Daniel J; Bharadwaj, Manish S; Jorgensen, Matthew J et al. (2017) Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev 2017:7317251
Callahan, Kathryn E; Wilson, Lindsay A; Pavon, Juliessa M et al. (2017) Internal Medicine Residents' Ambulatory Management of Core Geriatric Conditions. J Grad Med Educ 9:338-344
Brinkley, Tina E; Leng, Xiaoyan; Nicklas, Barbara J et al. (2017) Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Metabolism 70:98-106
Houston, Denise K; Tooze, Janet A; Garcia, Katelyn et al. (2017) Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc 65:1705-1711
Pogacnik Murillo, Aarón Leonardo; Eckstein, Felix; Wirth, Wolfgang et al. (2017) Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial. Cells Tissues Organs 203:258-266
Kitzman, Dalane W; Haykowsky, Mark J; Tomczak, Corey R (2017) Making the Case for Skeletal Muscle Myopathy and Its Contribution to Exercise Intolerance in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail 10:
King, Abby C; Salvo, Deborah; Banda, Jorge A et al. (2017) Preserving older adults' routine outdoor activities in contrasting neighborhood environments through a physical activity intervention. Prev Med 96:87-93
Shaltout, Hossam A; Eggebeen, Joel; Marsh, Anthony P et al. (2017) Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction. Nitric Oxide 69:78-90

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