The Biolmaging Resource Core (BRC) provides leadership, scientific expertise, and instrumental support in quantitative imaging, including MRI, CT, DXA and ultrasound, critical to the WFU OAlC's research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. The BRC Is integrated with all OAIC cores and leads the development and Implementation of imaging techniques and protocols to quantify and characterize body composition, especially skeletal (muscle and total, regional, and organ-specific adipose and fibrotic) tissue, and to obtain non-invasive measures of cardiovascular, nervous, vital organ, and musculoskeletal function. The Core also supports a robust image repository developed during the current cycle to facilitate cross-study comparisons and exploratory analyses of established imaging outcomes and rapid development and validation of new imaging phenotypes. During the present cycle, the BRC has contributed to the success of the OAIC by supporting 5,882 image acquisitions (DXA, CT, MRI &PET) in 7 pilot studies, 2 RCDC projects, and 8 externally-supported studies. This resulted in 49 peer-reviewed original publications and 9 new, extramurally funded grants, including a Ktype career development award and a Biolmaging T-32 training program, one of only 4 such NIH-funded programs in the U.S. Together, these awards total over $12 million in direct costs.
The specific aims of the BRC for the new cycle are to: 1) support pilot, developmental, and externally funded research projects by providing quantitative imaging phenotypes to be used as outcomes, mediators, effect modifiers and exposures in both observational and intervention research focused on identifying and evaluating factors affecting pathways to physical disability;2) develop capabilities for assessment of new OAlC-relevant imaging measures, including skeletal muscle cell lipid content, replacement fibrosis, perfusion, and oxygenation and integrate these with existing imaging protocols in older adults;3) extend the application of advanced imaging techniques in support of the OAICs programmatic goals by assisting junior faculty to integrate imaging into their work, collaborating with other OAIC Cores and investigators to develop multidisciplinary translational projects, and sharing with investigators beyond WFU. In the initial year, the BRC will support 4 pilot projects, 1 developmental project, and 6 externally-funded projects. The BRC leadership team is composed of highly experienced, independently successful investigators with complementary skill sets and strong records of collaborative scientific and administrative achievements who will ensure achievement of the BRC goals and its contributions to the success of the WFU OAIC.

Public Health Relevance

The Biolmaging Resource Core uses its expertise in biomedical imaging to help other scientists perform research that determines how features of body composition (muscle mass, fat distribution) and function (tissue perfusion or distribution of blood flow during exercise) contribute toward or help delay age-related changes in disability.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Wake Forest University Health Sciences
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Murphy, Rachel A; Hagaman, Ashley K; Reinders, Ilse et al. (2016) Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci 71:228-35
Gill, Thomas M; Pahor, Marco; Guralnik, Jack M et al. (2016) Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 352:i245
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2016) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc :
Klepin, Heidi D; Tooze, Janet A; Pardee, Timothy S et al. (2016) Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. J Am Geriatr Soc 64:1988-1995
Kitzman, Dalane W; Haykowsky, Mark J (2016) Vascular Dysfunction in Heart Failure with Preserved Ejection Fraction. J Card Fail 22:12-6
Marsh, Anthony P; Applegate, William B; Guralnik, Jack M et al. (2016) Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 64:933-43
Kheirkhahan, Matin; Tudor-Locke, Catrine; Axtell, Robert et al. (2016) Actigraphy features for predicting mobility disability in older adults. Physiol Meas 37:1813-1833
Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816
Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519
Messi, María Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80

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