The Biolmaging Resource Core (BRC) provides leadership, scientific expertise, and instrumental support in quantitative imaging, including MRI, CT, DXA and ultrasound, critical to the WFU OAlC's research theme: Integrating pathways affecting physical function for new approaches to disability treatment and prevention. The BRC Is integrated with all OAIC cores and leads the development and Implementation of imaging techniques and protocols to quantify and characterize body composition, especially skeletal (muscle and total, regional, and organ-specific adipose and fibrotic) tissue, and to obtain non-invasive measures of cardiovascular, nervous, vital organ, and musculoskeletal function. The Core also supports a robust image repository developed during the current cycle to facilitate cross-study comparisons and exploratory analyses of established imaging outcomes and rapid development and validation of new imaging phenotypes. During the present cycle, the BRC has contributed to the success of the OAIC by supporting 5,882 image acquisitions (DXA, CT, MRI &PET) in 7 pilot studies, 2 RCDC projects, and 8 externally-supported studies. This resulted in 49 peer-reviewed original publications and 9 new, extramurally funded grants, including a Ktype career development award and a Biolmaging T-32 training program, one of only 4 such NIH-funded programs in the U.S. Together, these awards total over $12 million in direct costs.
The specific aims of the BRC for the new cycle are to: 1) support pilot, developmental, and externally funded research projects by providing quantitative imaging phenotypes to be used as outcomes, mediators, effect modifiers and exposures in both observational and intervention research focused on identifying and evaluating factors affecting pathways to physical disability;2) develop capabilities for assessment of new OAlC-relevant imaging measures, including skeletal muscle cell lipid content, replacement fibrosis, perfusion, and oxygenation and integrate these with existing imaging protocols in older adults;3) extend the application of advanced imaging techniques in support of the OAICs programmatic goals by assisting junior faculty to integrate imaging into their work, collaborating with other OAIC Cores and investigators to develop multidisciplinary translational projects, and sharing with investigators beyond WFU. In the initial year, the BRC will support 4 pilot projects, 1 developmental project, and 6 externally-funded projects. The BRC leadership team is composed of highly experienced, independently successful investigators with complementary skill sets and strong records of collaborative scientific and administrative achievements who will ensure achievement of the BRC goals and its contributions to the success of the WFU OAIC.

Public Health Relevance

The Biolmaging Resource Core uses its expertise in biomedical imaging to help other scientists perform research that determines how features of body composition (muscle mass, fat distribution) and function (tissue perfusion or distribution of blood flow during exercise) contribute toward or help delay age-related changes in disability.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021332-11
Application #
8673581
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
Project End
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
11
Fiscal Year
2013
Total Cost
$86,339
Indirect Cost
$28,002
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Tyrrell, Daniel J; Bharadwaj, Manish S; Van Horn, Cynthia G et al. (2015) Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci 70:1394-9
Wrights, Abbie P; Fain, Christie W; Miller, Michael E et al. (2015) Assessing physical and cognitive function of older adults in continuing care retirement communities: who are we recruiting? Contemp Clin Trials 40:159-65
Beavers, K M; Beavers, D P; Newman, J J et al. (2015) Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis. Osteoarthritis Cartilage 23:249-56
Murphy, Rachel A; Reinders, Ilse; Register, Thomas C et al. (2014) Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults. Am J Clin Nutr 99:1059-65
Buford, Thomas W; Hsu, Fang-Chi; Brinkley, Tina E et al. (2014) Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Physiol Genomics 46:149-58
Pamukoff, Derek N; Haakonssen, Eric C; Zaccaria, Joseph A et al. (2014) The effects of strength and power training on single-step balance recovery in older adults: a preliminary study. Clin Interv Aging 9:697-704
Kitzman, Dalane W; Nicklas, Barbara; Kraus, William E et al. (2014) Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol 306:H1364-70
Klepin, Heidi D; Geiger, Ann M; Bandos, Hanna et al. (2014) Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Cancer Prev Res (Phila) 7:161-8
Groban, Leanne; Kitzman, Dalane W; Register, Thomas C et al. (2014) Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med 76:137-46
Grosicki, Gregory J; Miller, Michael E; Marsh, Anthony P (2014) Resistance exercise performance variability at submaximal intensities in older and younger adults. Clin Interv Aging 9:209-18

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