The goal of the WFU OAIC Biostatistics and Research Information Systems Core (BIC) is to build upon our strong successes in biostatistical collaboration and to develop a broader class of statistics/informatics tools that are tailored to research in aging. The proposed Core is comprised of a team of highly qualified investigators/staff with expertise in the design and management of observational, pilot and interventional studies, centralized and decentralized data management, forms design and data processing, image archival, psychometrics, statistical analysis of data from multiple study designs, GWAS analyses, and development of novel statistical methods. These individuals are committed to the WFU OAlC's global aims to: (1) discover;(2) evaluate;and (3) translate interventions to treat and prevent disability based on integrating novel pathways of functional decline;and (4) train the next generation of leaders in aging research.
The Specific Aims of the BIC are: 1. To participate as co-investigators for WFU OAIC projects (4 pilot studies (PES), 1 developmental projects (DP) and 8 externally funded projects (EPs)) related to OAlC's global aims. As co investigators, BIC members will be actively involved in study design and conduct (including recruitment monitoring, randomization, and safety monitoring);sample size determination;data management;and statistical analysis, interpretation and presentation/publication of results. 2. To play an integral role in training of OAlC-supported fellows and junior members of the BIC on the design, planning, conduct, and analysis of aging-related research projects. The BIC will also extend its strong record of discovery and evaluation with Specific Aims 3-4, which are to: 3. Develop additional innovative biostatistical applications/methods for analytical issues specifically associated with aging research. 4. Develop innovative research information collection systems to assist in carrying out studies in older participants and translate these tools into community- and clinic-based settings, in support of Aim 3 of the WFU OAIC overall goals.
By providing critical infrastructure needed for study design, data collection, analysis and interpretation, the Biostatistics and Research Information Systems Core will play a pivotal role in scientific investigations to advance our knowledge of the aging process. Core members will develop new data collection and analysis tools and will participate in translation of these tools into clinic and community settings.
|Murphy, Rachel A; Hagaman, Ashley K; Reinders, Ilse et al. (2016) Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci 71:228-35|
|Gill, Thomas M; Pahor, Marco; Guralnik, Jack M et al. (2016) Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 352:i245|
|Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2016) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc :|
|Klepin, Heidi D; Tooze, Janet A; Pardee, Timothy S et al. (2016) Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. J Am Geriatr Soc 64:1988-1995|
|Kitzman, Dalane W; Haykowsky, Mark J (2016) Vascular Dysfunction in Heart Failure with Preserved Ejection Fraction. J Card Fail 22:12-6|
|Marsh, Anthony P; Applegate, William B; Guralnik, Jack M et al. (2016) Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 64:933-43|
|Kheirkhahan, Matin; Tudor-Locke, Catrine; Axtell, Robert et al. (2016) Actigraphy features for predicting mobility disability in older adults. Physiol Meas 37:1813-1833|
|Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816|
|Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519|
|Messi, MarÃa Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80|
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