;The Wake Forest University (WFU) OAIC Coordinating Center Core (CCC) will facilitate and coordinate OAIC activities, and work closely with the OAIC Pis/Directors and the NIA program officers to provide administration for the overall OAIC program. Since 2005, the WFU CCC has turned these administrative functions into innovative activities that promote the development of OAIC faculty, multiply the power of OAIC research and resources by engaging the broader community of science, and foster use of OAICs as an integrated research network while maintaining the independence and strength of each center and its theme. Three key innovations in this proposal will advance the CCC to a new level of service benefitting all OAICs, NIA/NIH programs, and the larger aging/disability research community. 1) The OAIC Visiting Scholars Program (VSP) is supported by key leaders in aging research outside the OAICs who have agreed to co-fund scholars at the coordinating sites for the NIA Intramural program, the Women's Health Initiative Southeast Coordinating Center, and the Resource Centers for Minority Aging Research (RCMARs). The OAIC VSP will provide research fellowships for junior faculty to spend extended periods (2-6 weeks) at the coordinating centers of these large, epidemiologic networks focused on aging and functional outcomes. 2) SCALE-UP OAIC is a unique program to accelerate translation of OAIC research. Many OAICs are particularly skilled in smaller, mechanistic studies, but those centers often lack expertise to """"""""scale up"""""""" intervention studies to the next steps in translation. That skill set, however, is well represented in the OAIC network at large and we propose mechanisms to facilitate the transition of small (n = 10-20 participants) mechanistic studies to larger proof-of-concept clinical studies. 3) Wide dissemination of OAIC advances through Annual Meeting Highlights and top OAIC abstracts published as an annual feature in the Journal of the American Geriatrics Society. In addition to these key innovations, the WFU CCC has demonstrated a unique capacity to foster collaborations among other OAICs and engage other research networks (e.g. Centers for AIDS Research) to substantially leverage OAIC resources bringing new dollars and shared infrastructure to aging and disability research. These efforts will continue during the renewal period with specific grant applications on behalf of the entire OAIC network, and ongoing technology development to support data sharing.

Public Health Relevance

The Coordinating Center Core facilitates interactions and leverages resources that connect the 13 Pepper Centers around the nation. This function is essential to the rapid dissemination and implementation of research nationwide to maintain and improve the physical function and independence of older adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG021332-12
Application #
8698695
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
$224,965
Indirect Cost
$72,961
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Murphy, Rachel A; Hagaman, Ashley K; Reinders, Ilse et al. (2016) Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci 71:228-35
Gill, Thomas M; Pahor, Marco; Guralnik, Jack M et al. (2016) Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 352:i245
Beavers, Kristen M; Leng, Iris; Rapp, Stephen R et al. (2016) Effects of Longitudinal Glucose Exposure on Cognitive and Physical Function: Results from the Action for Health in Diabetes Movement and Memory Study. J Am Geriatr Soc :
Klepin, Heidi D; Tooze, Janet A; Pardee, Timothy S et al. (2016) Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. J Am Geriatr Soc 64:1988-1995
Kitzman, Dalane W; Haykowsky, Mark J (2016) Vascular Dysfunction in Heart Failure with Preserved Ejection Fraction. J Card Fail 22:12-6
Marsh, Anthony P; Applegate, William B; Guralnik, Jack M et al. (2016) Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 64:933-43
Kheirkhahan, Matin; Tudor-Locke, Catrine; Axtell, Robert et al. (2016) Actigraphy features for predicting mobility disability in older adults. Physiol Meas 37:1813-1833
Li, Xiaotong; Santago 2nd, Anthony C; Vidt, Meghan E et al. (2016) Analysis of effects of loading and postural demands on upper limb reaching in older adults using statistical parametric mapping. J Biomech 49:2806-2816
Hall, Michael E; Brinkley, Tina E; Chughtai, Haroon et al. (2016) Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One 11:e0146519
Messi, María Laura; Li, Tao; Wang, Zhong-Min et al. (2016) Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults. J Gerontol A Biol Sci Med Sci 71:1273-80

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