. ,V The long-term objective ofthe Research Career Development Core (RCDC) is the establishment of a core of well-trained, highly motivated junior faculty who will become leaders and mentors in scholarship on frailty and its translation into the prevention and amelioration of frailty in older adults. The RCDC accomplishes this objective through progress through five specific aims: 1) It partners with the Leadership Council ofthe LAC to identify, attract, and select outstanding junior faculty from a variety of disciplines with the interest and potential to become future leaders in the field of frailty and preservation of independence for older adults. 2) It provides the research infrastructure, salary support and protected time essential to enable the selected faculty to successfully bridge the critical transition between fellowship and independent grant funding. 3) It provides mentorship with both team-based and one-on-one elements so as to promote, benchmark, and assure research progress and career development. 4) It designs for each supported individual a program of subject-area, methodological and leadership training to equip him/her for their career goals, and promotes its successful completion. 5) It creates a welcoming academic home and 'stimulus zone'for junior faculty, postdoctoral fellows, and predoctoral students invested in frailty-related scholarship through forums for ongoing networking and intellectual enrichment between RCDC-supported investigators and all other OAIC supported investigators including monthly research-in-progress sessions and sponsorship of working group meetings, seminars and guest lecturers in collaboration with partnering institutional resources on aging. Resources are prioritized, first, to K-eligible individuals, followed by R-eligible individuals and then to other trainees so as to direct Core efforts to support at a key transitional point, when research careers are often in jeopardy because of lack of funding and research infrastructure. The leadership of this Core and the OAIC as a whole will continue to emphasize training across disciplines and toward translation between basic science and clinical investigation. The Core aims to produce aging- and frailty-focused independent investigators who will lead research whose application will improve independence in older adults.

Public Health Relevance

Frailty is a frequent adverse outcome of .aging which makes older adults vulnerable to many other adverse outcomes including loss of independence. As a syndrome with a complex etiology, its study requires a multidisciplinary cadre of dedicated, expert scholars who will determine its etiology and methods to ameliorate it. Thus this Core's development of junior researchers with the interdisciplinary skills to lead in the needed discovery stand to improve health and quality of life for millions in our expanding older population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021334-11
Application #
8673895
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
Project End
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
11
Fiscal Year
2013
Total Cost
$279,892
Indirect Cost
$107,119
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Walston, Jeremy; Robinson, Thomas N; Zieman, Susan et al. (2017) Integrating Frailty Research into the Medical Specialties-Report from a U13 Conference. J Am Geriatr Soc 65:2134-2139
Weiss, Kilian; Schär, Michael; Panjrath, Gurusher S et al. (2017) Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure. Circ Heart Fail 10:
McAdams-DeMarco, Mara A; King, Elizabeth A; Luo, Xun et al. (2017) Frailty, Length of Stay, and Mortality in Kidney Transplant Recipients: A National Registry and Prospective Cohort Study. Ann Surg 266:1084-1090
Buta, Brian; Choudhury, Parichoy Pal; Xue, Qian-Li et al. (2017) The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases. J Am Geriatr Soc 65:619-624
Graham, Antonio; Brown 4th, Charles H (2017) Frailty, Aging, and Cardiovascular Surgery. Anesth Analg 124:1053-1060
McAdams-DeMarco, Mara A; Ying, Hao; Olorundare, Israel et al. (2017) Individual Frailty Components and Mortality in Kidney Transplant Recipients. Transplantation 101:2126-2132
Tan, Jingwen; Bae, Sunjae; Segal, Jodi B et al. (2017) Warfarin Use And the Risk Of Stroke, Bleeding, And Mortality In Older Adults On Dialysis With Incident Atrial Fibrillation. Nephrology (Carlton) :
Piggott, Damani A; Muzaale, Abimereki D; Varadhan, Ravi et al. (2017) Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci 72:389-394
Kucharska-Newton, Anna M; Palta, Priya; Burgard, Sheila et al. (2017) Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort. J Gerontol A Biol Sci Med Sci 72:382-388
Wyrobek, J; LaFlam, A; Max, L et al. (2017) Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults. Br J Anaesth 119:324-332

Showing the most recent 10 out of 220 publications