. ,V The long-term objective ofthe Research Career Development Core (RCDC) is the establishment of a core of well-trained, highly motivated junior faculty who will become leaders and mentors in scholarship on frailty and its translation into the prevention and amelioration of frailty in older adults. The RCDC accomplishes this objective through progress through five specific aims: 1) It partners with the Leadership Council ofthe LAC to identify, attract, and select outstanding junior faculty from a variety of disciplines with the interest and potential to become future leaders in the field of frailty and preservation of independence for older adults. 2) It provides the research infrastructure, salary support and protected time essential to enable the selected faculty to successfully bridge the critical transition between fellowship and independent grant funding. 3) It provides mentorship with both team-based and one-on-one elements so as to promote, benchmark, and assure research progress and career development. 4) It designs for each supported individual a program of subject-area, methodological and leadership training to equip him/her for their career goals, and promotes its successful completion. 5) It creates a welcoming academic home and 'stimulus zone'for junior faculty, postdoctoral fellows, and predoctoral students invested in frailty-related scholarship through forums for ongoing networking and intellectual enrichment between RCDC-supported investigators and all other OAIC supported investigators including monthly research-in-progress sessions and sponsorship of working group meetings, seminars and guest lecturers in collaboration with partnering institutional resources on aging. Resources are prioritized, first, to K-eligible individuals, followed by R-eligible individuals and then to other trainees so as to direct Core efforts to support at a key transitional point, when research careers are often in jeopardy because of lack of funding and research infrastructure. The leadership of this Core and the OAIC as a whole will continue to emphasize training across disciplines and toward translation between basic science and clinical investigation. The Core aims to produce aging- and frailty-focused independent investigators who will lead research whose application will improve independence in older adults.

Public Health Relevance

Frailty is a frequent adverse outcome of .aging which makes older adults vulnerable to many other adverse outcomes including loss of independence. As a syndrome with a complex etiology, its study requires a multidisciplinary cadre of dedicated, expert scholars who will determine its etiology and methods to ameliorate it. Thus this Core's development of junior researchers with the interdisciplinary skills to lead in the needed discovery stand to improve health and quality of life for millions in our expanding older population.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Varma, Vijay R; Carlson, Michelle C; Parisi, Jeanine M et al. (2015) Experience Corps Baltimore: Exploring the Stressors and Rewards of High-intensity Civic Engagement. Gerontologist 55:1038-49
Varma, Vijay R; Chuang, Yi-Fang; Harris, Gregory C et al. (2015) Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus 25:605-15
McAdams-DeMarco, Mara A; Law, Andrew; Tan, Jingwen et al. (2015) Frailty, mycophenolate reduction, and graft loss in kidney transplant recipients. Transplantation 99:805-10
Corriere, Mark D; Minang, Laura B; Sisson, Stephen D et al. (2014) The use of clinical guidelines highlights ongoing educational gaps in physicians' knowledge and decision making related to diabetes. BMC Med Educ 14:186
Salter, Megan L; McAdams-Demarco, Mara A; Law, Andrew et al. (2014) Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc 62:843-9
Chuang, Yi-Fang; Eldreth, Dana; Erickson, Kirk I et al. (2014) Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging 35:1396-403
McAdams-Demarco, M A; Grams, M E; King, E et al. (2014) Sequelae of early hospital readmission after kidney transplantation. Am J Transplant 14:397-403
Kalyani, Rita R; Tra, Y; Egan, J M et al. (2014) Hyperglycemia is associated with relatively lower lean body mass in older adults. J Nutr Health Aging 18:737-43
Weinreich, Heather M; Agrawal, Yuri (2014) The link between allergy and Menière's disease. Curr Opin Otolaryngol Head Neck Surg 22:227-30
Tan, Erwin J; McGill, Sylvia; Tanner, Elizabeth K et al. (2014) The evolution of an academic-community partnership in the design, implementation, and evaluation of experience corpsýý Baltimore city: a courtship model. Gerontologist 54:314-21

Showing the most recent 10 out of 102 publications