The identification of the etiologies of frailty and age-related vulnerability remains one of the most important challenges in Gerontologic research. Key to this challenge is the development of a better understanding of the underlying biological basis that contributes to frailty, and the identification of key biological pathways for the development of interventions that might help prevent or alleviate frailty and loss of independence. The purpose of Johns Hopkins Older Americans Independence Center (OAIC) Biological Mechanisms Core (RC- 2) is to provide access to a broad array of state of the art biological measurement resources that will enable the next generation of frailty-focused discovery. In addition, RC2 will provide biological samples, and facilitate training, mentorship and translation around biological mechanisms that impact the development of frailty and declines in independence.
The specific aims of RC2 are 1) to provide state of the art scientific expertise, infrastructure, and technology necessarily to forward biological and etiological research related to frailty, 2) to provide access to biological samples from human subjects and from animal models necessary to test hypotheses related to frailty, 3) to facilitate the translation of biological findings into interventions or prevention focused clinical studies, 4) to provide training, mentorship, and guidance to promising junior investigators around biological mechanisms that impact frailty, and 5) to provide institutional and external visibility for RC-2 related science and activities, the human resources, infrastructure, and training necessary to facilitate the highest quality genetic and molecular studies related to frailty, the overall focus of the Hopkins OAIC.
These aims will be accomplished through close collaboration between the interdisciplinary core leaders and their laboratories, the leadership of the other OAIC cores, and through the engagement of highly expert consultants in the highly relevant areas of epigenetic, telomere biology, mitochondrial function, mouse model development, and nanotechnologies and proteomics. By providing these resources, RC-2 will foster high quality research that elucidate clinically relevant biological pathways that underlie frailty, and related interventions that attenuate frailty and loss of independence.

Public Health Relevance

Frailty is an aging related condition that is likely due to declines in multiple biological systems. Key to understanding the complex biology that contributes to frailty and loss of independence will be the effective use and integration of important new biological technologies in to frailty research. The results of these biological discovery efforts can then better inform the development of targeted treatment strategies.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Varma, Vijay R; Carlson, Michelle C; Parisi, Jeanine M et al. (2015) Experience Corps Baltimore: Exploring the Stressors and Rewards of High-intensity Civic Engagement. Gerontologist 55:1038-49
Varma, Vijay R; Chuang, Yi-Fang; Harris, Gregory C et al. (2015) Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus 25:605-15
McAdams-DeMarco, Mara A; Law, Andrew; Tan, Jingwen et al. (2015) Frailty, mycophenolate reduction, and graft loss in kidney transplant recipients. Transplantation 99:805-10
Corriere, Mark D; Minang, Laura B; Sisson, Stephen D et al. (2014) The use of clinical guidelines highlights ongoing educational gaps in physicians' knowledge and decision making related to diabetes. BMC Med Educ 14:186
Salter, Megan L; McAdams-Demarco, Mara A; Law, Andrew et al. (2014) Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc 62:843-9
Chuang, Yi-Fang; Eldreth, Dana; Erickson, Kirk I et al. (2014) Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging 35:1396-403
McAdams-Demarco, M A; Grams, M E; King, E et al. (2014) Sequelae of early hospital readmission after kidney transplantation. Am J Transplant 14:397-403
Kalyani, Rita R; Tra, Y; Egan, J M et al. (2014) Hyperglycemia is associated with relatively lower lean body mass in older adults. J Nutr Health Aging 18:737-43
Weinreich, Heather M; Agrawal, Yuri (2014) The link between allergy and Menière's disease. Curr Opin Otolaryngol Head Neck Surg 22:227-30
Tan, Erwin J; McGill, Sylvia; Tanner, Elizabeth K et al. (2014) The evolution of an academic-community partnership in the design, implementation, and evaluation of experience corpsýý Baltimore city: a courtship model. Gerontologist 54:314-21

Showing the most recent 10 out of 102 publications