Established in 1992, the Yale Older Americans Independence Center (OAIC) seeks to continue providing intellectual leadership and innovation for aging research that aims to enhance independence. Our unifying theme remains the investigation of multifactorial geriatric health conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. Our premise is that health conditions common in older adults are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health domains. The predisposing factors may be at genetic, physiologic (impairment), disease, or socio-demographic levels, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. What distinguishes Yale OAIC research is that its purpose is to investigate the interactions among, or intervene on, multiple factors simultaneously and to measure the effect of conditions or interventions on a range of health domains.
The Aims of the Yale OAIC are to: 1) develop the careers of future academic leaders in aging/geriatrics;2) train investigators and methodologists in the skills necessary to design, conduct, and analyze studies of multifactorial geriatric health conditions;3) develop design and analytic techniques for conducting studies of multifactorial geriatric health conditions;4) develop strategies for recruiting into, and retaining, a broad spectrum of older adults, including minorities, into OAIC studies;5) investigate the causative mechanisms of, and identify effective treatments for, health conditions experienced by older adults from a multifactorial research perspective;6) develop outcome measures for use in investigating multifactorial geriatric health conditions and for studying older adults with multiple coexisting conditions;and 7) facilitate basic, translational, and interdisciplinary research that connects to our focus on multifactorial geriatric health conditions. The Yale OAIC cores include: 1) Leadership / Administrative;2) Research Career Development;3) Pilot/Exploratory;5) Biostatistics;6) Data Management / Informatics;and 7) Field. For the first years of the next cycle, we propose to support 4 RCDC candidates;4 pilot studies (including 2 by RCDC candidates);1 computational biology development study;and 14 externally funded projects.
|Mohanty, Subhasis; Joshi, Samit R; Ueda, Ikuyo et al. (2015) Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis 211:1174-84|
|Hartaigh, Bríain ó; Allore, Heather G; Trentalange, Mark et al. (2015) Elevations in time-varying resting heart rate predict subsequent all-cause mortality in older adults. Eur J Prev Cardiol 22:527-34|
|Erekson, Elisabeth A; Ciarleglio, Maria M; Hanissian, Paul D et al. (2015) Functional disability and compromised mobility among older women with urinary incontinence. Female Pelvic Med Reconstr Surg 21:170-5|
|Erekson, Elisabeth A; Ciarleglio, Maria M; Hanissian, Paul D et al. (2015) Functional disability among older women with fecal incontinence. Am J Obstet Gynecol 212:327.e1-7|
|Xu, Xiao; Liang, Jersey; Bennett, Joan M et al. (2015) Socioeconomic stratification and multidimensional health trajectories: evidence of convergence in later old age. J Gerontol B Psychol Sci Soc Sci 70:661-71|
|Bradley, Elizabeth H; Sipsma, Heather; Brewster, Amanda L et al. (2014) Strategies to reduce hospital 30-day risk-standardized mortality rates for patients with acute myocardial infarction: a cross-sectional and longitudinal survey. BMC Cardiovasc Disord 14:126|
|Lin, Haiqun; Han, Ling; Peduzzi, Peter N et al. (2014) A dynamic trajectory class model for intensive longitudinal categorical outcome. Stat Med 33:2645-64|
|Dodson, John A; Geda, Mary; Krumholz, Harlan M et al. (2014) Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study. BMC Health Serv Res 14:506|
|Greysen, S Ryan; Hoi-Cheung, Doug; Garcia, Veronica et al. (2014) "Missing pieces"--functional, social, and environmental barriers to recovery for vulnerable older adults transitioning from hospital to home. J Am Geriatr Soc 62:1556-61|
|Yao, Yi; Liu, Rebecca; Shin, Min Sun et al. (2014) CyTOF supports efficient detection of immune cell subsets from small samples. J Immunol Methods 415:1-5|
Showing the most recent 10 out of 332 publications