Established in 1992, the Yale Older Americans Independence Center (OAIC) seeks to continue providing intellectual leadership and innovation for aging research that aims to enhance independence. Our unifying theme remains the investigation of multifactorial geriatric health conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. Our premise is that health conditions common in older adults are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health domains. The predisposing factors may be at genetic, physiologic (impairment), disease, or socio-demographic levels, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. What distinguishes Yale OAIC research is that its purpose is to investigate the interactions among, or intervene on, multiple factors simultaneously and to measure the effect of conditions or interventions on a range of health domains.
The Aims of the Yale OAIC are to: 1) develop the careers of future academic leaders in aging/geriatrics;2) train investigators and methodologists in the skills necessary to design, conduct, and analyze studies of multifactorial geriatric health conditions;3) develop design and analytic techniques for conducting studies of multifactorial geriatric health conditions;4) develop strategies for recruiting into, and retaining, a broad spectrum of older adults, including minorities, into OAIC studies;5) investigate the causative mechanisms of, and identify effective treatments for, health conditions experienced by older adults from a multifactorial research perspective;6) develop outcome measures for use in investigating multifactorial geriatric health conditions and for studying older adults with multiple coexisting conditions;and 7) facilitate basic, translational, and interdisciplinary research that connects to our focus on multifactorial geriatric health conditions. The Yale OAIC cores include: 1) Leadership / Administrative;2) Research Career Development;3) Pilot/Exploratory;5) Biostatistics;6) Data Management / Informatics;and 7) Field. For the first years of the next cycle, we propose to support 4 RCDC candidates;4 pilot studies (including 2 by RCDC candidates);1 computational biology development study;and 14 externally funded projects.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
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Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
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Eldadah, Basil A
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Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
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Fried, Terri; Zenoni, Maria; Iannone, Lynne (2016) A Dyadic Perspective on Engagement in Advance Care Planning. J Am Geriatr Soc :
Fried, Terri R; Niehoff, Kristina; Tjia, Jennifer et al. (2016) A Delphi process to address medication appropriateness for older persons with multiple chronic conditions. BMC Geriatr 16:67
Ó Hartaigh, Bríain; Lovato, Laura C; Pahor, Marco et al. (2016) Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc 64:2511-2516
Malawista, Anna; Wang, Xiaomei; Trentalange, Mark et al. (2016) Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny. Macrophage (Houst) 3:
Feder, Shelli L; Schulman-Green, Dena; Dodson, John A et al. (2016) Risk Stratification in Older Patients With Acute Myocardial Infarction: Physicians' Perspectives. J Aging Health 28:387-402
Weiner, Melissa R; Monin, Joan K; Mota, Natalie et al. (2016) Age Differences in the Association of Social Support and Mental Health in Male U.S. Veterans: Results From the National Health and Resilience in Veterans Study. Am J Geriatr Psychiatry 24:327-36
Snyder, Peter J; Bhasin, Shalender; Cunningham, Glenn R et al. (2016) Effects of Testosterone Treatment in Older Men. N Engl J Med 374:611-24
Bramley, Kyle; Pisani, Margaret A; Murphy, Terrence E et al. (2016) Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. Ann Thorac Surg 101:1870-6
Miner, Brienne; Tinetti, Mary E; Van Ness, Peter H et al. (2016) Dyspnea in Community-Dwelling Older Persons: A Multifactorial Geriatric Health Condition. J Am Geriatr Soc 64:2042-2050
Ferrante, Lauren E; Pisani, Margaret A; Murphy, Terrence E et al. (2016) Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. Am J Respir Crit Care Med 194:299-307

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