The mission of the Yale Older Americans Independence Center (OAIC), established in 1992, is to provide intellectual leadership and innovation for aging research that is directed at enhancing the independence of older persons. The unifying theme of the Yale OAIC remains the investigation of multifactorial geriatric health conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. The Yale OAIC hypothesis is that geriatric health conditions are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health outcomes. The predisposing factors may be at the genetic, molecular, physiologic, impairment, disease, or socio-demographic level, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. As a related subtheme, the Yale OAIC also aims to advance the science of clinical decision making in the face of tradeoffs and multiple competing outcomes. This includes developing strategies to elicit older persons'health outcome priorities.
The Specific Aims of the Yale OAIC are to: 1) foster the career development of future academic leaders, from multiple disciplines, in aging research;2) train investigators, biostatisticians and other methodologists in the skills necessary to design, conduct, analyze, and disseminate findings from studies of multifactorial geriatric health conditions;3) develop and disseminate design and analytic techniques for conducting studies of multifactorial geriatric health conditions;4) develop strategies for recruiting into, and retainin, a broad spectrum of older persons, including minorities, into studies of multifactorial geriatric health conditions;5) investigate the causative mechanisms of, and develop and test effective treatments for, geriatric health conditions from a multifactorial research perspective;6) develop strategies to enhance clinical decision making in the setting of multiple health conditions;7) encourage and facilitate interdisciplinary research (basic, translational and clinical) that connects to our focus on multifactorial geriatric health conditions;and 8) develop and implement strategies that will facilitate the translation of OAIC research into practice and policy. The Yale OAIC cores include: 1) Leadership and Administrative;2) Research Career Development;3) Pilot/Exploratory Studies;4) Operations;5) Biostatistics;and 6) Information Dissemination. For the first 1 to 2 years of the next cycle, we propose to support 4 RCDC candidates, 3 pilot studies, 2 development projects, and 17 externally funded projects.

Public Health Relevance

The Yale OAIC will promote the functional independence of older Americans by increasing scientific knowledge related to multifactorial geriatric health conditions, by advancing the science of clinical decision making in multimorbid older adults, and by educating and training new investigators in research on aging from a multifactorial perspective.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
2P30AG021342-11
Application #
8470837
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8 (J1))
Program Officer
Eldadah, Basil A
Project Start
2002-09-30
Project End
2018-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
11
Fiscal Year
2013
Total Cost
$1,154,714
Indirect Cost
$461,192
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Fried, Terri; Zenoni, Maria; Iannone, Lynne (2016) A Dyadic Perspective on Engagement in Advance Care Planning. J Am Geriatr Soc :
Fried, Terri R; Niehoff, Kristina; Tjia, Jennifer et al. (2016) A Delphi process to address medication appropriateness for older persons with multiple chronic conditions. BMC Geriatr 16:67
Ó Hartaigh, Bríain; Lovato, Laura C; Pahor, Marco et al. (2016) Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders Study. J Am Geriatr Soc 64:2511-2516
Malawista, Anna; Wang, Xiaomei; Trentalange, Mark et al. (2016) Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny. Macrophage (Houst) 3:
Feder, Shelli L; Schulman-Green, Dena; Dodson, John A et al. (2016) Risk Stratification in Older Patients With Acute Myocardial Infarction: Physicians' Perspectives. J Aging Health 28:387-402
Weiner, Melissa R; Monin, Joan K; Mota, Natalie et al. (2016) Age Differences in the Association of Social Support and Mental Health in Male U.S. Veterans: Results From the National Health and Resilience in Veterans Study. Am J Geriatr Psychiatry 24:327-36
Snyder, Peter J; Bhasin, Shalender; Cunningham, Glenn R et al. (2016) Effects of Testosterone Treatment in Older Men. N Engl J Med 374:611-24
Bramley, Kyle; Pisani, Margaret A; Murphy, Terrence E et al. (2016) Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. Ann Thorac Surg 101:1870-6
Miner, Brienne; Tinetti, Mary E; Van Ness, Peter H et al. (2016) Dyspnea in Community-Dwelling Older Persons: A Multifactorial Geriatric Health Condition. J Am Geriatr Soc 64:2042-2050
Ferrante, Lauren E; Pisani, Margaret A; Murphy, Terrence E et al. (2016) Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. Am J Respir Crit Care Med 194:299-307

Showing the most recent 10 out of 523 publications