The primary objective ofthe Biostatistics Core (BC) is to provide state-of-the-art design and analytical services to investigators conducting studies that advance the Yale OAIC theme of multifactorial geriatric health conditions. The two major BC goals are to develop and disseminate new design and analytical techniques for conducting studies with older adults through Development Projects and External Projects (EPs), and to train clinical investigators, biostatisticians, and epidemiologists in the skills necessary to design, conduct, and analyze aging research studies. The goals ofthe BC are achieved under the direction of the Core Leader and Co-Leader who have both worked at the Yale OAIC for the past 10 years and who have served in their current leadership roles since 2006. BC investigators have rich experience in collaborative research, proven expertise in interdisciplinary and translational methods, and stable leadership in planning, administering, and supervising Core activities, providing strong assurance of continued success during the next funding cycle.
The Specific Aims ofthe BC are: (1) to collaborate with Pepper Scholars, PESC investigators, the Operations Core, and investigators of EPs to achieve the mission ofthe Yale OAIC in promoting the understanding and treatment of multifactorial geriatric health conditions;(2) to develop new and sound methods that address the challenges of designing and analyzing studies in basic, translational, and clinical geriatric/aging research, with special emphasis on introducing statistical methods from other disciplines;and (3) to train the next generation of statisticians, epidemiologists and junior investigators in Gerontologic Biostatistics research methods specific to studies of multifactorial geriatric health conditions. Administratively, the BC will implement a set of standard operating procedures, assign biostatisticians and related resources to Yale OAIC projects, oversee analytical procedures, communicate with other Cores and EP investigators, and publish statistical results. The distinctive intellectual contributions ofthe BC involve identifying areas where there are gaps in knowledge about the design, conduct, and analysis of studies of multifactorial geriatric health conditions and then developing and applying new methods to address these gaps in knowledge.

Public Health Relevance

The Biostatistics Core will address the multifactorial nature of geriatric health conditions, including the co occurrence of multiple predisposing and precipitating factors, and will advance the science of clinical decision-making in the face of trade-offs and multiple competing outcomes by developing and applying innovative statistical designs and analytic methods and by training the next generation of investigators in these methods.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
New Haven
United States
Zip Code
Mohanty, Subhasis; Joshi, Samit R; Ueda, Ikuyo et al. (2015) Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis 211:1174-84
Hartaigh, Bríain ó; Allore, Heather G; Trentalange, Mark et al. (2015) Elevations in time-varying resting heart rate predict subsequent all-cause mortality in older adults. Eur J Prev Cardiol 22:527-34
Erekson, Elisabeth A; Ciarleglio, Maria M; Hanissian, Paul D et al. (2015) Functional disability and compromised mobility among older women with urinary incontinence. Female Pelvic Med Reconstr Surg 21:170-5
Erekson, Elisabeth A; Ciarleglio, Maria M; Hanissian, Paul D et al. (2015) Functional disability among older women with fecal incontinence. Am J Obstet Gynecol 212:327.e1-7
Xu, Xiao; Liang, Jersey; Bennett, Joan M et al. (2015) Socioeconomic stratification and multidimensional health trajectories: evidence of convergence in later old age. J Gerontol B Psychol Sci Soc Sci 70:661-71
Bradley, Elizabeth H; Sipsma, Heather; Brewster, Amanda L et al. (2014) Strategies to reduce hospital 30-day risk-standardized mortality rates for patients with acute myocardial infarction: a cross-sectional and longitudinal survey. BMC Cardiovasc Disord 14:126
Lin, Haiqun; Han, Ling; Peduzzi, Peter N et al. (2014) A dynamic trajectory class model for intensive longitudinal categorical outcome. Stat Med 33:2645-64
Dodson, John A; Geda, Mary; Krumholz, Harlan M et al. (2014) Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study. BMC Health Serv Res 14:506
Greysen, S Ryan; Hoi-Cheung, Doug; Garcia, Veronica et al. (2014) "Missing pieces"--functional, social, and environmental barriers to recovery for vulnerable older adults transitioning from hospital to home. J Am Geriatr Soc 62:1556-61
Yao, Yi; Liu, Rebecca; Shin, Min Sun et al. (2014) CyTOF supports efficient detection of immune cell subsets from small samples. J Immunol Methods 415:1-5

Showing the most recent 10 out of 332 publications