Whatever the underlying physiologic or neurologic mechanisms, questions about loss of mobility, deterioration of motor control, responses to impending falls, maintenance of balance and postural control, changes in muscle contraction characteristics and maintenance of continence are ultimately biomechanical questions (Ashton-Miller &Alexander, 2003). The facilities of the Biomechanics Core will enable examination of such questions quantitatively, from the viewpoint of biomechanics and other physiological measurements. In particular the Biomechanics Core will contribute to the mission of the UM Pepper Center by fostering research Into the mechanisms by which certain predictor and modifying variables earlier in life may affect the expression of aged phenotypes. Applications of Biomechanics Research: There is ample justification for funding research and research training that help examine the role of biomechanical and other physiological mechanisms that contribute to the aged phenotypes as well as to physical impairments, syndromes and disability in elderfy people. The insights such research will provide apply to (1) designing diagnostic tests that can quantify precisely physical impairment in elderiy people, (2) designing more effective therapy programs for elderiy people who are already impaired, (3) designing protocols, such as exercise protocols, for prevention of physical impairments in elderiy people. Areas of particular interest include aging, gait on regular and irregular surfaces, mobility, fall-related injuries, as well as female pelvic floor function, urinary incontinence and prolapse, and (4) in transferring technology from bench to bedside. The latter goals are consistent with the CDC Injury Prevention Agenda 2009-2018 (National Center for Injury Prevention and Control, 2009).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Center Core Grants (P30)
Project #
5P30AG024824-10
Application #
8525277
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
10
Fiscal Year
2013
Total Cost
$85,759
Indirect Cost
$30,251
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Li, Weiquan; Miller, Richard A (2015) Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. J Gerontol A Biol Sci Med Sci 70:263-72
Min, Lillian; Mazzurco, Lauren; Gure, Tanya R et al. (2015) Longitudinal functional recovery after geriatric cardiac surgery. J Surg Res 194:25-33
Park, Hwan-Woo; Park, Haeli; Ro, Seung-Hyun et al. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress. Nat Commun 5:4233
Min, Lillian; Reuben, David; Karlamangla, Arun et al. (2014) Abbreviated care-process quality indicator sets linked with survival and functional status benefit in older adults under ambulatory care. J Am Geriatr Soc 62:1442-50
Ro, Seung-Hyun; Nam, Myeongjin; Jang, Insook et al. (2014) Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Proc Natl Acad Sci U S A 111:7849-54
Mody, Lona; Juthani-Mehta, Manisha (2014) Urinary tract infections in older women: a clinical review. JAMA 311:844-54
Nicklett, Emily J; Taylor, Robert Joseph (2014) Racial/Ethnic predictors of falls among older adults: the health and retirement study. J Aging Health 26:1060-75
Rao, Krishna (2014) Measuring the impact of Clostridium difficile Infection with the NAP1 strain on severity and mortality. Clin Infect Dis 59:1193-4
Rao, Krishna; Young, Vincent B; Aronoff, David M (2014) Fecal microbiota therapy: ready for prime time? Infect Control Hosp Epidemiol 35:28-30
Tillou, Areti; Kelley-Quon, Lorraine; Burruss, Sigrid et al. (2014) Long-term postinjury functional recovery: outcomes of geriatric consultation. JAMA Surg 149:83-9

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